Efficient gene editing in adult mouse livers via adenoviral delivery of CRISPR/Cas9

•Adenoviral delivery of CRISPR/Cas9 produces efficient gene editing in cultured cells.•Effective gene knockout in the adult mouse liver via adenoviral delivery of CRISPR/Cas9.•The gene editing in the liver is stable over long term and after extensive liver tissue regeneration. We developed an adenov...

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Veröffentlicht in:	FEBS letters 2014-11, Vol.588 (21), p.3954-3958
Hauptverfasser:	Cheng, Ranran, Peng, Jin, Yan, Yonghong, Cao, Peili, Wang, Jiewei, Qiu, Chen, Tang, Lichun, Liu, Di, Tang, Li, Jin, Jianping, Huang, Xingxu, He, Fuchu, Zhang, Pumin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviruses Animals Base Sequence Clustered Regularly Interspaced Short Palindromic Repeats - genetics CRISPR/Cas9 Gene editing Gene Targeting - methods Humans Liver Liver - metabolism Male Mice
Online-Zugang:	Volltext
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