Collagen remodeling and peripheral immune cell recruitment characterizes the cutaneous Langerhans cell histiocytosis microenvironment

Background Langerhans cell histiocytosis (LCH) is a rare and potentially fatal disorder of unknown etiology arising from the accumulation of epidermal Langerhans‐like cells in bone, skin, or other tissues. Tissue damage and morbidity results from lesional cytokine release, and we sought to investiga...

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Veröffentlicht in:	International journal of dermatology 2015-01, Vol.54 (1), p.e7-e13
Hauptverfasser:	Harikumar, Parvathy E., Selway, Joanne L., Chu, Anthony, Langlands, Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	Collagen - ultrastructure Elastic Tissue - pathology Extracellular Matrix - pathology Female Granulocytes Histiocytosis, Langerhans-Cell - immunology Histiocytosis, Langerhans-Cell - pathology Humans Immunochemistry Macrophages Male Mast Cells Skin Diseases - immunology Skin Diseases - pathology T-Lymphocytes
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