The Antimicrobial Activities of Phenylbutyrates against Helicobacter pylori
Three phenyl derivatives of butyrate, 2-phenylbutyrate (2-PB), 3-phenylbutyrate (3-PB) and 4-phenylbutyrate (4-PB), were evaluated in terms of their antibacterial and cytotoxic activities. Our results indicated that PBs demonstrated specific inhibitory activity against Helicobacter pylori and Escher...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2013/06/01, Vol.61(6), pp.604-610 |
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| creator | Lo, Chung-Yi Cheng, Hsueh-Ling Hsu, Jue-Liang Liao, Ming-Hui Yen, Rong-Lang Chen, Yo-Chia |
| description | Three phenyl derivatives of butyrate, 2-phenylbutyrate (2-PB), 3-phenylbutyrate (3-PB) and 4-phenylbutyrate (4-PB), were evaluated in terms of their antibacterial and cytotoxic activities. Our results indicated that PBs demonstrated specific inhibitory activity against Helicobacter pylori and Escherichia coli but did not influence the growth of Bifidobacterium bifidium and Lactobacillus reuteri. PBs also exhibited synergistic effects on H. pylori ATCC 43504 especially at pH 5.5. In the protein expression profiles in H. pylori treated by phenylbutyrates, we also found that three protein spots identified as oxidative stress-related proteins were significantly up-regulated, confirming the response of H. pylori when exposed to PBs. Due to their antibacterial activities and low or slight cytotoxicities, PBs are potential candidates for the treatment of H. pylori infection. This is the first study to discover the antibiotic effects of 2-PB, 3-PB and 4-PB (Buphenyl). |
| doi_str_mv | 10.1248/cpb.c12-00857 |
| format | Article |
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Our results indicated that PBs demonstrated specific inhibitory activity against Helicobacter pylori and Escherichia coli but did not influence the growth of Bifidobacterium bifidium and Lactobacillus reuteri. PBs also exhibited synergistic effects on H. pylori ATCC 43504 especially at pH 5.5. In the protein expression profiles in H. pylori treated by phenylbutyrates, we also found that three protein spots identified as oxidative stress-related proteins were significantly up-regulated, confirming the response of H. pylori when exposed to PBs. Due to their antibacterial activities and low or slight cytotoxicities, PBs are potential candidates for the treatment of H. pylori infection. This is the first study to discover the antibiotic effects of 2-PB, 3-PB and 4-PB (Buphenyl).</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.c12-00857</identifier><identifier>PMID: 23727774</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>2-phenylbutyrate ; 3-phenylbutyrate ; 4-phenylbutyrate ; Animals ; Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; Anti-Infective Agents - toxicity ; Bacterial Proteins - metabolism ; Bifidobacterium ; Bifidobacterium - drug effects ; Bifidobacterium - growth & development ; Buphenyl ; Cell Line ; Cell Survival - drug effects ; Cricetinae ; Drug Synergism ; Escherichia coli ; Escherichia coli - drug effects ; Helicobacter pylori ; Helicobacter pylori - drug effects ; Helicobacter pylori - metabolism ; Hydrogen-Ion Concentration ; Lactobacillus reuteri ; Lactobacillus reuteri - drug effects ; Lactobacillus reuteri - growth & development ; Metronidazole - pharmacology ; Microbial Sensitivity Tests ; Phenylbutyrates - chemistry ; Phenylbutyrates - pharmacology ; Phenylbutyrates - toxicity ; Up-Regulation</subject><ispartof>Chemical and Pharmaceutical Bulletin, 2013/06/01, Vol.61(6), pp.604-610</ispartof><rights>2013 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c735t-a2cc086fe5d4c492e445f53488a5d1d84e6884bccb01f1a205fe680efa2507023</citedby><cites>FETCH-LOGICAL-c735t-a2cc086fe5d4c492e445f53488a5d1d84e6884bccb01f1a205fe680efa2507023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23727774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lo, Chung-Yi</creatorcontrib><creatorcontrib>Cheng, Hsueh-Ling</creatorcontrib><creatorcontrib>Hsu, Jue-Liang</creatorcontrib><creatorcontrib>Liao, Ming-Hui</creatorcontrib><creatorcontrib>Yen, Rong-Lang</creatorcontrib><creatorcontrib>Chen, Yo-Chia</creatorcontrib><creatorcontrib>Department of Biological Science & Technology</creatorcontrib><creatorcontrib>Graduate Institute of Bioresource</creatorcontrib><creatorcontrib>National Pingtung University of Science and Technology</creatorcontrib><creatorcontrib>Antromed Biotech.Inc</creatorcontrib><creatorcontrib>Department of Veterinary Medicine</creatorcontrib><title>The Antimicrobial Activities of Phenylbutyrates against Helicobacter pylori</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Three phenyl derivatives of butyrate, 2-phenylbutyrate (2-PB), 3-phenylbutyrate (3-PB) and 4-phenylbutyrate (4-PB), were evaluated in terms of their antibacterial and cytotoxic activities. Our results indicated that PBs demonstrated specific inhibitory activity against Helicobacter pylori and Escherichia coli but did not influence the growth of Bifidobacterium bifidium and Lactobacillus reuteri. PBs also exhibited synergistic effects on H. pylori ATCC 43504 especially at pH 5.5. In the protein expression profiles in H. pylori treated by phenylbutyrates, we also found that three protein spots identified as oxidative stress-related proteins were significantly up-regulated, confirming the response of H. pylori when exposed to PBs. Due to their antibacterial activities and low or slight cytotoxicities, PBs are potential candidates for the treatment of H. pylori infection. This is the first study to discover the antibiotic effects of 2-PB, 3-PB and 4-PB (Buphenyl).</description><subject>2-phenylbutyrate</subject><subject>3-phenylbutyrate</subject><subject>4-phenylbutyrate</subject><subject>Animals</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Anti-Infective Agents - toxicity</subject><subject>Bacterial Proteins - metabolism</subject><subject>Bifidobacterium</subject><subject>Bifidobacterium - drug effects</subject><subject>Bifidobacterium - growth & development</subject><subject>Buphenyl</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>Cricetinae</subject><subject>Drug Synergism</subject><subject>Escherichia coli</subject><subject>Escherichia coli - drug effects</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - drug effects</subject><subject>Helicobacter pylori - metabolism</subject><subject>Hydrogen-Ion Concentration</subject><subject>Lactobacillus reuteri</subject><subject>Lactobacillus reuteri - drug effects</subject><subject>Lactobacillus reuteri - growth & development</subject><subject>Metronidazole - pharmacology</subject><subject>Microbial Sensitivity Tests</subject><subject>Phenylbutyrates - chemistry</subject><subject>Phenylbutyrates - pharmacology</subject><subject>Phenylbutyrates - toxicity</subject><subject>Up-Regulation</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1vEzEQhi0EomnhyBWtxIXLlvG3e4wiaCsqwaGcLa8z2zjy7gbbqZR_j7cpqcSFi0eeefTOx0vIBwqXlAnzxe-6S09ZC2CkfkUWlAvdSsb4a7IAgKuWccXPyHnOWwAmQfO35IxxzbTWYkG-32-wWY4lDMGnqQsuNktfwmMoAXMz9c3PDY6H2O3LIblSU-7BhTGX5gZj8FPnfMHU7A5xSuEdedO7mPH9c7wgv759vV_dtHc_rm9Xy7vWay5L65j3YFSPci28uGIohOwlF8Y4uaZrI1AZIzrvO6A9dQxkXzOAvZvHB8YvyOej7i5Nv_eYix1C9hijG3HaZ0uVFEpX1vwf5UpoMCBlRT_9g26nfRrrIpYKbYDXY-pKtUeqXivnhL3dpTC4dLAU7GyIrYbYaoh9MqTyH59V992A6xP914EKXB-BWg3exWmMYcSX3j5rv8EhWAaUV1FFQdVQ9RUIO38ZME3ZvOvqqLTNxT3gqZVLJfiIT4MpatX8nAZ8qW5csjjyPwMZs6s</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Lo, Chung-Yi</creator><creator>Cheng, Hsueh-Ling</creator><creator>Hsu, Jue-Liang</creator><creator>Liao, Ming-Hui</creator><creator>Yen, Rong-Lang</creator><creator>Chen, Yo-Chia</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20130601</creationdate><title>The Antimicrobial Activities of Phenylbutyrates against Helicobacter pylori</title><author>Lo, Chung-Yi ; Cheng, Hsueh-Ling ; Hsu, Jue-Liang ; Liao, Ming-Hui ; Yen, Rong-Lang ; Chen, Yo-Chia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c735t-a2cc086fe5d4c492e445f53488a5d1d84e6884bccb01f1a205fe680efa2507023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>2-phenylbutyrate</topic><topic>3-phenylbutyrate</topic><topic>4-phenylbutyrate</topic><topic>Animals</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Anti-Infective Agents - toxicity</topic><topic>Bacterial Proteins - metabolism</topic><topic>Bifidobacterium</topic><topic>Bifidobacterium - drug effects</topic><topic>Bifidobacterium - growth & development</topic><topic>Buphenyl</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>Cricetinae</topic><topic>Drug Synergism</topic><topic>Escherichia coli</topic><topic>Escherichia coli - drug effects</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - drug effects</topic><topic>Helicobacter pylori - metabolism</topic><topic>Hydrogen-Ion Concentration</topic><topic>Lactobacillus reuteri</topic><topic>Lactobacillus reuteri - drug effects</topic><topic>Lactobacillus reuteri - growth & development</topic><topic>Metronidazole - pharmacology</topic><topic>Microbial Sensitivity Tests</topic><topic>Phenylbutyrates - chemistry</topic><topic>Phenylbutyrates - pharmacology</topic><topic>Phenylbutyrates - toxicity</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lo, Chung-Yi</creatorcontrib><creatorcontrib>Cheng, Hsueh-Ling</creatorcontrib><creatorcontrib>Hsu, Jue-Liang</creatorcontrib><creatorcontrib>Liao, Ming-Hui</creatorcontrib><creatorcontrib>Yen, Rong-Lang</creatorcontrib><creatorcontrib>Chen, Yo-Chia</creatorcontrib><creatorcontrib>Department of Biological Science & Technology</creatorcontrib><creatorcontrib>Graduate Institute of Bioresource</creatorcontrib><creatorcontrib>National Pingtung University of Science and Technology</creatorcontrib><creatorcontrib>Antromed Biotech.Inc</creatorcontrib><creatorcontrib>Department of Veterinary Medicine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lo, Chung-Yi</au><au>Cheng, Hsueh-Ling</au><au>Hsu, Jue-Liang</au><au>Liao, Ming-Hui</au><au>Yen, Rong-Lang</au><au>Chen, Yo-Chia</au><aucorp>Department of Biological Science & Technology</aucorp><aucorp>Graduate Institute of Bioresource</aucorp><aucorp>National Pingtung University of Science and Technology</aucorp><aucorp>Antromed Biotech.Inc</aucorp><aucorp>Department of Veterinary Medicine</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Antimicrobial Activities of Phenylbutyrates against Helicobacter pylori</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>61</volume><issue>6</issue><spage>604</spage><epage>610</epage><pages>604-610</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Three phenyl derivatives of butyrate, 2-phenylbutyrate (2-PB), 3-phenylbutyrate (3-PB) and 4-phenylbutyrate (4-PB), were evaluated in terms of their antibacterial and cytotoxic activities. Our results indicated that PBs demonstrated specific inhibitory activity against Helicobacter pylori and Escherichia coli but did not influence the growth of Bifidobacterium bifidium and Lactobacillus reuteri. PBs also exhibited synergistic effects on H. pylori ATCC 43504 especially at pH 5.5. In the protein expression profiles in H. pylori treated by phenylbutyrates, we also found that three protein spots identified as oxidative stress-related proteins were significantly up-regulated, confirming the response of H. pylori when exposed to PBs. Due to their antibacterial activities and low or slight cytotoxicities, PBs are potential candidates for the treatment of H. pylori infection. This is the first study to discover the antibiotic effects of 2-PB, 3-PB and 4-PB (Buphenyl).</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>23727774</pmid><doi>10.1248/cpb.c12-00857</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Chemical and Pharmaceutical Bulletin, 2013/06/01, Vol.61(6), pp.604-610 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Free Full-Text Journals in Chemistry |
| subjects | 2-phenylbutyrate 3-phenylbutyrate 4-phenylbutyrate Animals Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Anti-Infective Agents - toxicity Bacterial Proteins - metabolism Bifidobacterium Bifidobacterium - drug effects Bifidobacterium - growth & development Buphenyl Cell Line Cell Survival - drug effects Cricetinae Drug Synergism Escherichia coli Escherichia coli - drug effects Helicobacter pylori Helicobacter pylori - drug effects Helicobacter pylori - metabolism Hydrogen-Ion Concentration Lactobacillus reuteri Lactobacillus reuteri - drug effects Lactobacillus reuteri - growth & development Metronidazole - pharmacology Microbial Sensitivity Tests Phenylbutyrates - chemistry Phenylbutyrates - pharmacology Phenylbutyrates - toxicity Up-Regulation |
| title | The Antimicrobial Activities of Phenylbutyrates against Helicobacter pylori |
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