Perforin is a novel immune regulator of obesity-related insulin resistance

Obesity-related insulin resistance is associated with an influx of pathogenic T cells into visceral adipose tissue (VAT), but the mechanisms regulating lymphocyte balance in such tissues are unknown. Here we describe an important role for the immune cytotoxic effector molecule perforin in regulating...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2015-01, Vol.64 (1), p.90-103
Hauptverfasser:	Revelo, Xavier S, Tsai, Sue, Lei, Helena, Luck, Helen, Ghazarian, Magar, Tsui, Hubert, Shi, Sally Y, Schroer, Stephanie, Luk, Cynthia T, Lin, Gloria H Y, Mak, Tak W, Woo, Minna, Winer, Shawn, Winer, Daniel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - cytology Bone Marrow Cells - immunology CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell Line Cytotoxicity Diabetes Diet, High-Fat Embryonic Stem Cells - cytology Female Glucose Intolerance - genetics Glucose Intolerance - immunology Glucose Intolerance - metabolism Homeostasis Insulin - metabolism Insulin resistance Insulin Resistance - immunology Intra-Abdominal Fat - immunology Intra-Abdominal Fat - metabolism Lymph Nodes - cytology Lymph Nodes - immunology Male Mice, Inbred C57BL Mice, Knockout Obesity - genetics Obesity - immunology Obesity - metabolism Panniculitis - genetics Panniculitis - immunology Panniculitis - metabolism Perforin - genetics Perforin - immunology Perforin - metabolism Proteins Rodents Spleen - cytology Spleen - immunology T cell receptors
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