Honokiol Induces Cell Cycle Arrest and Apoptosis Via Inhibiting Class I Histone Deacetylases in Acute Myeloid Leukemia

ABSTRACT Honokiol, a constituent of Magnolia officinalis, has been reported to possess potent anti‐cancer activity through targeting multiple signaling pathways in numerous malignancies including acute myeloid leukemia (AML). However, the underlying mechanisms remain to be defined. Here, we report t...

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Veröffentlicht in:	Journal of cellular biochemistry 2015-02, Vol.116 (2), p.287-298
Hauptverfasser:	Li, Hai-Ying, Ye, Hai-Ge, Chen, Chi-Qi, Yin, Li-Hui, Wu, Jian-Bo, He, Li-Cai, Gao, Shen-Meng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Adult Aged Animals Apoptosis - drug effects BAX bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biocatalysis - drug effects Biphenyl Compounds - pharmacology Blotting, Western Cell Cycle Checkpoints - drug effects Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Drugs, Chinese Herbal - pharmacology Female HISTONE DEACETYLASES Histone Deacetylases - metabolism HONOKIOL Humans K562 Cells Leukemia, Myeloid - drug therapy Leukemia, Myeloid - genetics Leukemia, Myeloid - metabolism Lignans - pharmacology Magnolia Male Mice, Nude Middle Aged P21/WAF1 Proteasome Endopeptidase Complex - metabolism Reverse Transcriptase Polymerase Chain Reaction Tumor Cells, Cultured Xenograft Model Antitumor Assays
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