Investigating the mode of action of sulfoxaflor: a fourth‐generation neonicotinoid
BACKGROUND: The precise mode of action of sulfoxaflor, a new nicotinic acetylcholine receptor‐modulating insecticide, is unclear. A detailed understanding of the mode of action, especially in relation to the neonicotinoids, is essential for recommending effective pest management practices. RESULTS:...
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| Veröffentlicht in: | Pest management science 2013-05, Vol.69 (5), p.607-619 |
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| creator | Cutler, Penny Slater, Russell Edmunds, Andrew JF Maienfisch, Peter Hall, Roger G Earley, Fergus GP Pitterna, Thomas Pal, Sitaram Paul, Verity‐Laura Goodchild, Jim Blacker, Melissa Hagmann, Leonhard Crossthwaite, Andrew J |
| description | BACKGROUND: The precise mode of action of sulfoxaflor, a new nicotinic acetylcholine receptor‐modulating insecticide, is unclear. A detailed understanding of the mode of action, especially in relation to the neonicotinoids, is essential for recommending effective pest management practices. RESULTS: Radiolabel binding experiments using a tritiated analogue of sulfoxaflor ([³H]‐methyl‐SFX) performed on membranes from Myzus persicae demonstrate that sulfoxaflor interacts specifically with the high‐affinity imidacloprid binding site present in a subpopulation of the total nAChR pool. In competition studies, imidacloprid‐like neonicotinoids displace [³H]‐methyl‐SFX at pM concentrations. The effects of sulfoxaflor on the exposed aphid nervous system in situ are analogous to those of imidacloprid and nitenpyram, and finally the high‐affinity sulfoxaflor binding site is absent in a Myzus persicae strain (clone FRC) possessing a single amino acid point mutation (R81T) in the β‐nAChR, a region critical for neonicotinoid interaction. CONCLUSION: The nicotinic acetylcholine receptor pharmacological profile of sulfoxaflor in aphids is consistent with that of imidacloprid. Additionally, the insecticidal activity of sulfoxaflor and the current commercialised neonicotinoids is affected by the point mutation in FRC Myzus persicae. Therefore, it is suggested that sulfoxalfor be considered a neonicotinoid, and that this be taken into account when recommending insecticide rotation partnering for effective resistance management programmes. © 2012 Society of Chemical Industry |
| doi_str_mv | 10.1002/ps.3413 |
| format | Article |
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A detailed understanding of the mode of action, especially in relation to the neonicotinoids, is essential for recommending effective pest management practices. RESULTS: Radiolabel binding experiments using a tritiated analogue of sulfoxaflor ([³H]‐methyl‐SFX) performed on membranes from Myzus persicae demonstrate that sulfoxaflor interacts specifically with the high‐affinity imidacloprid binding site present in a subpopulation of the total nAChR pool. In competition studies, imidacloprid‐like neonicotinoids displace [³H]‐methyl‐SFX at pM concentrations. The effects of sulfoxaflor on the exposed aphid nervous system in situ are analogous to those of imidacloprid and nitenpyram, and finally the high‐affinity sulfoxaflor binding site is absent in a Myzus persicae strain (clone FRC) possessing a single amino acid point mutation (R81T) in the β‐nAChR, a region critical for neonicotinoid interaction. CONCLUSION: The nicotinic acetylcholine receptor pharmacological profile of sulfoxaflor in aphids is consistent with that of imidacloprid. Additionally, the insecticidal activity of sulfoxaflor and the current commercialised neonicotinoids is affected by the point mutation in FRC Myzus persicae. Therefore, it is suggested that sulfoxalfor be considered a neonicotinoid, and that this be taken into account when recommending insecticide rotation partnering for effective resistance management programmes. © 2012 Society of Chemical Industry</description><identifier>ISSN: 1526-498X</identifier><identifier>EISSN: 1526-4998</identifier><identifier>DOI: 10.1002/ps.3413</identifier><identifier>PMID: 23112103</identifier><identifier>CODEN: PMSCFC</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Aphididae ; Aphids ; Binding sites ; Binding, Competitive ; Biological and medical sciences ; Control ; Fundamental and applied biological sciences. Psychology ; Imidacloprid ; insecticidal properties ; Insecticide Resistance ; Insecticides ; Insecticides - toxicity ; Insects ; mechanism of action ; Mutation ; Myzus persicae ; nervous system ; nicotinic acetylcholine receptor ; nitenpyram ; Pest control ; pest management ; Phytopathology. Animal pests. Plant and forest protection ; point mutation ; Protozoa. Invertebrates ; Pyridines - chemical synthesis ; Pyridines - toxicity ; radiolabel ; Receptors, Nicotinic - chemistry ; resistance ; resistance management ; Sulfur Compounds - chemical synthesis ; Sulfur Compounds - toxicity ; Tritium</subject><ispartof>Pest management science, 2013-05, Vol.69 (5), p.607-619</ispartof><rights>2012 Society of Chemical Industry</rights><rights>2014 INIST-CNRS</rights><rights>2012 Society of Chemical Industry.</rights><rights>Copyright Wiley Subscription Services, Inc. May 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5363-90266cddb471d5c55ce7663e5450b718e7479f3582ce3590d555b8f1791059063</citedby><cites>FETCH-LOGICAL-c5363-90266cddb471d5c55ce7663e5450b718e7479f3582ce3590d555b8f1791059063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fps.3413$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fps.3413$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27242712$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23112103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cutler, Penny</creatorcontrib><creatorcontrib>Slater, Russell</creatorcontrib><creatorcontrib>Edmunds, Andrew JF</creatorcontrib><creatorcontrib>Maienfisch, Peter</creatorcontrib><creatorcontrib>Hall, Roger G</creatorcontrib><creatorcontrib>Earley, Fergus GP</creatorcontrib><creatorcontrib>Pitterna, Thomas</creatorcontrib><creatorcontrib>Pal, Sitaram</creatorcontrib><creatorcontrib>Paul, Verity‐Laura</creatorcontrib><creatorcontrib>Goodchild, Jim</creatorcontrib><creatorcontrib>Blacker, Melissa</creatorcontrib><creatorcontrib>Hagmann, Leonhard</creatorcontrib><creatorcontrib>Crossthwaite, Andrew J</creatorcontrib><title>Investigating the mode of action of sulfoxaflor: a fourth‐generation neonicotinoid</title><title>Pest management science</title><addtitle>Pest. Manag. Sci</addtitle><description>BACKGROUND: The precise mode of action of sulfoxaflor, a new nicotinic acetylcholine receptor‐modulating insecticide, is unclear. A detailed understanding of the mode of action, especially in relation to the neonicotinoids, is essential for recommending effective pest management practices. RESULTS: Radiolabel binding experiments using a tritiated analogue of sulfoxaflor ([³H]‐methyl‐SFX) performed on membranes from Myzus persicae demonstrate that sulfoxaflor interacts specifically with the high‐affinity imidacloprid binding site present in a subpopulation of the total nAChR pool. In competition studies, imidacloprid‐like neonicotinoids displace [³H]‐methyl‐SFX at pM concentrations. The effects of sulfoxaflor on the exposed aphid nervous system in situ are analogous to those of imidacloprid and nitenpyram, and finally the high‐affinity sulfoxaflor binding site is absent in a Myzus persicae strain (clone FRC) possessing a single amino acid point mutation (R81T) in the β‐nAChR, a region critical for neonicotinoid interaction. CONCLUSION: The nicotinic acetylcholine receptor pharmacological profile of sulfoxaflor in aphids is consistent with that of imidacloprid. Additionally, the insecticidal activity of sulfoxaflor and the current commercialised neonicotinoids is affected by the point mutation in FRC Myzus persicae. Therefore, it is suggested that sulfoxalfor be considered a neonicotinoid, and that this be taken into account when recommending insecticide rotation partnering for effective resistance management programmes. © 2012 Society of Chemical Industry</description><subject>Animals</subject><subject>Aphididae</subject><subject>Aphids</subject><subject>Binding sites</subject><subject>Binding, Competitive</subject><subject>Biological and medical sciences</subject><subject>Control</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Imidacloprid</subject><subject>insecticidal properties</subject><subject>Insecticide Resistance</subject><subject>Insecticides</subject><subject>Insecticides - toxicity</subject><subject>Insects</subject><subject>mechanism of action</subject><subject>Mutation</subject><subject>Myzus persicae</subject><subject>nervous system</subject><subject>nicotinic acetylcholine receptor</subject><subject>nitenpyram</subject><subject>Pest control</subject><subject>pest management</subject><subject>Phytopathology. Animal pests. Plant and forest protection</subject><subject>point mutation</subject><subject>Protozoa. Invertebrates</subject><subject>Pyridines - chemical synthesis</subject><subject>Pyridines - toxicity</subject><subject>radiolabel</subject><subject>Receptors, Nicotinic - chemistry</subject><subject>resistance</subject><subject>resistance management</subject><subject>Sulfur Compounds - chemical synthesis</subject><subject>Sulfur Compounds - toxicity</subject><subject>Tritium</subject><issn>1526-498X</issn><issn>1526-4998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ttqFDEYAOBQlJ4svoEOFKlQps1hkky8k6UnXLTQLd27kM0k29TZyZrM9HDnI_iMPomZzrqCIF7lD3z8h_wB4DWCRwhCfLyMR6RAZANsI4pZXghRvljH5XQL7MR4ByEUQuBNsIUJQhhBsg0mF829ia2bq9Y186y9NdnCVybzNlO6db7po9jV1j8qW_vwIVOZ9V1ob39-_zE3jQnqWTXGN077lMS76hV4aVUdzd7q3AXXpyeT0Xk-_nJ2Mfo4zjUljOQCYsZ0Vc0KjiqqKdWGM0YMLSiccVQaXnBhCS2xNoQKWFFKZ6VFXCCYrozsgvdD3mXw37o0hly4qE1dq9ROFyVitGAszUz-TwlmHAvBcKL7f9G7NHCTBulVCTHCDCZ1MCgdfIzBWLkMbqHCk0RQ9juRyyj7nST5ZpWvmy1MtXa_l5DAuxVQUavaBtVoF_84jgvMUd_Y4eAeXG2e_lVPXl6tyuaDdrE1j2utwlfJOOFU3nw-k1P86Xw8mkxl_5hvB2-Vl2oeUgfXVxiiIn0bLqDg5Bd3o7f2</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Cutler, Penny</creator><creator>Slater, Russell</creator><creator>Edmunds, Andrew JF</creator><creator>Maienfisch, Peter</creator><creator>Hall, Roger G</creator><creator>Earley, Fergus GP</creator><creator>Pitterna, Thomas</creator><creator>Pal, Sitaram</creator><creator>Paul, Verity‐Laura</creator><creator>Goodchild, Jim</creator><creator>Blacker, Melissa</creator><creator>Hagmann, Leonhard</creator><creator>Crossthwaite, Andrew J</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7SS</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>201305</creationdate><title>Investigating the mode of action of sulfoxaflor: a fourth‐generation neonicotinoid</title><author>Cutler, Penny ; Slater, Russell ; Edmunds, Andrew JF ; Maienfisch, Peter ; Hall, Roger G ; Earley, Fergus GP ; Pitterna, Thomas ; Pal, Sitaram ; Paul, Verity‐Laura ; Goodchild, Jim ; Blacker, Melissa ; Hagmann, Leonhard ; Crossthwaite, Andrew J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5363-90266cddb471d5c55ce7663e5450b718e7479f3582ce3590d555b8f1791059063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Aphididae</topic><topic>Aphids</topic><topic>Binding sites</topic><topic>Binding, Competitive</topic><topic>Biological and medical sciences</topic><topic>Control</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Imidacloprid</topic><topic>insecticidal properties</topic><topic>Insecticide Resistance</topic><topic>Insecticides</topic><topic>Insecticides - toxicity</topic><topic>Insects</topic><topic>mechanism of action</topic><topic>Mutation</topic><topic>Myzus persicae</topic><topic>nervous system</topic><topic>nicotinic acetylcholine receptor</topic><topic>nitenpyram</topic><topic>Pest control</topic><topic>pest management</topic><topic>Phytopathology. Animal pests. Plant and forest protection</topic><topic>point mutation</topic><topic>Protozoa. Invertebrates</topic><topic>Pyridines - chemical synthesis</topic><topic>Pyridines - toxicity</topic><topic>radiolabel</topic><topic>Receptors, Nicotinic - chemistry</topic><topic>resistance</topic><topic>resistance management</topic><topic>Sulfur Compounds - chemical synthesis</topic><topic>Sulfur Compounds - toxicity</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cutler, Penny</creatorcontrib><creatorcontrib>Slater, Russell</creatorcontrib><creatorcontrib>Edmunds, Andrew JF</creatorcontrib><creatorcontrib>Maienfisch, Peter</creatorcontrib><creatorcontrib>Hall, Roger G</creatorcontrib><creatorcontrib>Earley, Fergus GP</creatorcontrib><creatorcontrib>Pitterna, Thomas</creatorcontrib><creatorcontrib>Pal, Sitaram</creatorcontrib><creatorcontrib>Paul, Verity‐Laura</creatorcontrib><creatorcontrib>Goodchild, Jim</creatorcontrib><creatorcontrib>Blacker, Melissa</creatorcontrib><creatorcontrib>Hagmann, Leonhard</creatorcontrib><creatorcontrib>Crossthwaite, Andrew J</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pest management science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cutler, Penny</au><au>Slater, Russell</au><au>Edmunds, Andrew JF</au><au>Maienfisch, Peter</au><au>Hall, Roger G</au><au>Earley, Fergus GP</au><au>Pitterna, Thomas</au><au>Pal, Sitaram</au><au>Paul, Verity‐Laura</au><au>Goodchild, Jim</au><au>Blacker, Melissa</au><au>Hagmann, Leonhard</au><au>Crossthwaite, Andrew J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigating the mode of action of sulfoxaflor: a fourth‐generation neonicotinoid</atitle><jtitle>Pest management science</jtitle><addtitle>Pest. Manag. Sci</addtitle><date>2013-05</date><risdate>2013</risdate><volume>69</volume><issue>5</issue><spage>607</spage><epage>619</epage><pages>607-619</pages><issn>1526-498X</issn><eissn>1526-4998</eissn><coden>PMSCFC</coden><abstract>BACKGROUND: The precise mode of action of sulfoxaflor, a new nicotinic acetylcholine receptor‐modulating insecticide, is unclear. A detailed understanding of the mode of action, especially in relation to the neonicotinoids, is essential for recommending effective pest management practices. RESULTS: Radiolabel binding experiments using a tritiated analogue of sulfoxaflor ([³H]‐methyl‐SFX) performed on membranes from Myzus persicae demonstrate that sulfoxaflor interacts specifically with the high‐affinity imidacloprid binding site present in a subpopulation of the total nAChR pool. In competition studies, imidacloprid‐like neonicotinoids displace [³H]‐methyl‐SFX at pM concentrations. The effects of sulfoxaflor on the exposed aphid nervous system in situ are analogous to those of imidacloprid and nitenpyram, and finally the high‐affinity sulfoxaflor binding site is absent in a Myzus persicae strain (clone FRC) possessing a single amino acid point mutation (R81T) in the β‐nAChR, a region critical for neonicotinoid interaction. CONCLUSION: The nicotinic acetylcholine receptor pharmacological profile of sulfoxaflor in aphids is consistent with that of imidacloprid. Additionally, the insecticidal activity of sulfoxaflor and the current commercialised neonicotinoids is affected by the point mutation in FRC Myzus persicae. Therefore, it is suggested that sulfoxalfor be considered a neonicotinoid, and that this be taken into account when recommending insecticide rotation partnering for effective resistance management programmes. © 2012 Society of Chemical Industry</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>23112103</pmid><doi>10.1002/ps.3413</doi><tpages>13</tpages></addata></record> |
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| subjects | Animals Aphididae Aphids Binding sites Binding, Competitive Biological and medical sciences Control Fundamental and applied biological sciences. Psychology Imidacloprid insecticidal properties Insecticide Resistance Insecticides Insecticides - toxicity Insects mechanism of action Mutation Myzus persicae nervous system nicotinic acetylcholine receptor nitenpyram Pest control pest management Phytopathology. Animal pests. Plant and forest protection point mutation Protozoa. Invertebrates Pyridines - chemical synthesis Pyridines - toxicity radiolabel Receptors, Nicotinic - chemistry resistance resistance management Sulfur Compounds - chemical synthesis Sulfur Compounds - toxicity Tritium |
| title | Investigating the mode of action of sulfoxaflor: a fourth‐generation neonicotinoid |
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