IL‐27 stimulates human NK‐cell effector functions and primes NK cells for IL‐18 responsiveness

IL‐27, a member of the IL‐12 family of cytokines, is produced by APCs, and displays pro‐ and anti‐inflammatory effects. How IL‐27 affects human NK cells still remains unknown. In this study, we observed that mature DCs secreted IL‐27 and that blockade of IL‐27R (CD130) reduced the amount of IFN‐γ pr...

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Veröffentlicht in:	European journal of immunology 2015-01, Vol.45 (1), p.192-202
Hauptverfasser:	Ziblat, Andrea, Domaica, Carolina I., Spallanzani, Raúl G., Iraolagoitia, Ximena L. Raffo, Rossi, Lucas E., Avila, Damián E., Torres, Nicolás I., Fuertes, Mercedes B., Zwirner, Norberto W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology Antigens Antigens, CD - genetics Antigens, CD - immunology Antigens, Differentiation, T-Lymphocyte - genetics Antigens, Differentiation, T-Lymphocyte - immunology Cell Proliferation - drug effects Cell Survival - immunology Coculture Techniques Cytokine Receptor gp130 - genetics Cytokine Receptor gp130 - immunology Cytotoxicity Cytotoxicity, Immunologic Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - immunology Gene Expression Regulation HCT116 Cells Humans IFN‐γ IL‐18 IL‐27 Immune system Interleukin-18 - immunology Interleukin-18 - pharmacology Interleukin-2 Receptor alpha Subunit - genetics Interleukin-2 Receptor alpha Subunit - immunology Interleukins - immunology Interleukins - pharmacology Killer Cells, Natural - cytology Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lectins, C-Type - genetics Lectins, C-Type - immunology NK cells Primary Cell Culture Recombinant Proteins - pharmacology Signal Transduction
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