Enhanced gene delivery efficiency of cationic liposomes coated with PEGylated hyaluronic acid for anti P-glycoprotein siRNA: A potential candidate for overcoming multi-drug resistance

PEGylated hyaluronic acid (PEG–HA) was synthesized and employed to coat the cationic liposome-siRNA complex through electrostatic interaction to form PEG–HA–NP. Due to a reversed surface charge, PEG–HA–NP could keep stable in fetal bovine serum (FBS). In vitro studies demonstrated that PEG–HA–NP had...

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Veröffentlicht in:	International journal of pharmaceutics 2014-12, Vol.477 (1-2), p.590-600
Hauptverfasser:	Ran, Rui, Liu, Yayuan, Gao, Huile, Kuang, Qifang, Zhang, Qianyu, Tang, Jie, Huang, Kai, Chen, Xiaoxiao, Zhang, Zhirong, He, Qin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Cationic liposome Cations Cell Survival - genetics Drug Carriers - chemical synthesis Drug Carriers - chemistry Drug Resistance, Multiple - genetics Drug Resistance, Neoplasm - genetics Female Gene Silencing Gene Transfer Techniques Hyaluronic Acid - analogs & derivatives Hyaluronic Acid - chemical synthesis Hyaluronic Acid - chemistry MCF-7 Cells Mice, Nude P-glycoprotein downregulation PEGylated hyaluronic acid Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics RNA, Small Interfering - pharmacokinetics siRNA delivery Technology, Pharmaceutical - methods Tumor targeting delivery Xenograft Model Antitumor Assays
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