In Vivo Antileishmanial Efficacy of Miltefosine Against Leishmania (Leishmania) amazonensis

Leishmaniasis, a disease caused by parasites of the Leishmania genus, constitutes a significant health and social problem in many countries and is increasing worldwide. The conventional treatment, meglumine antimoniate (MA), presents numerous disadvantages, including invasiveness, toxicity, and freq...

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Veröffentlicht in:	The Journal of parasitology 2014-12, Vol.100 (6), p.840-847
Hauptverfasser:	García Bustos, María F, Barrio, Alejandra, Prieto, Gabriela G, de Raspi, Emma M, Cimino, Rubén O, Cardozo, Rubén M, Parada, Luis A, Yeo, Matthew, Soto, Jaime, Uncos, Delfor A, Parodi, Cecilia, Basombrío, Miguel A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amastigotes Animals Antibodies Antiprotozoal Agents - administration & dosage Antiprotozoal Agents - pharmacology Antiprotozoal Agents - therapeutic use Dosage histopathology Infections Leishmania amazonensis Leishmania mexicana - drug effects Leishmaniasis Leishmaniasis, Cutaneous - drug therapy Leishmaniasis, Cutaneous - parasitology Leishmaniasis, Cutaneous - pathology Lesions Liver Male Medical treatment Meglumine - administration & dosage Meglumine - pharmacology Meglumine - therapeutic use Mice Organometallic Compounds - administration & dosage Organometallic Compounds - pharmacology Organometallic Compounds - therapeutic use Parasites Phosphorylcholine - administration & dosage Phosphorylcholine - analogs & derivatives Phosphorylcholine - pharmacology Phosphorylcholine - therapeutic use polymerase chain reaction Spleen Spleen - pathology splenomegaly therapeutics THERAPEUTICS-DIAGNOSTICS toxicity
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