Inhibition of TNFα attenuates infarct volume and ICAM-1 expression in ischemic mouse brain
THE purpose of our study was to determine whether inhibiting the action of tumor necrosis factor-α (TNFα) attenuates brain injury and reduces inflammatory responses in the mouse during ischemia and reperfusion. Mice underwent middle cerebral artery occlusion (MCAO) for 1 h followed by 23 h reperfusi...
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| Veröffentlicht in: | Neuroreport 1998-06, Vol.9 (9), p.2131-2134 |
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| creator | Yang, Guo-Yuan Gong, Chao Qin, Zhen Ye, Wen Mao, Ying Bertz, A Lorris |
| description | THE purpose of our study was to determine whether inhibiting the action of tumor necrosis factor-α (TNFα) attenuates brain injury and reduces inflammatory responses in the mouse during ischemia and reperfusion. Mice underwent middle cerebral artery occlusion (MCAO) for 1 h followed by 23 h reperfusion. Monoclonal neutralizing anti-murine TNFα antibody (mAb) was administrated intraventricularly in the mouse with temporary MCAO. Infarct volume in the anti-TNFα mAb treated mice was significantly smaller than that in the control group (p < 0.05). The number of intercellular adhesion molecule-1 (ICAM-1)-positive vessels in the ischemic area of the anti-TNFα mAb-treated group was significantly less than that in the control group. Our study demonstrated that blocking TNFα reduced brain injury and attenuated ICAM-1 expression during transient cerebral ischemia. |
| doi_str_mv | 10.1097/00001756-199806220-00041 |
| format | Article |
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Mice underwent middle cerebral artery occlusion (MCAO) for 1 h followed by 23 h reperfusion. Monoclonal neutralizing anti-murine TNFα antibody (mAb) was administrated intraventricularly in the mouse with temporary MCAO. Infarct volume in the anti-TNFα mAb treated mice was significantly smaller than that in the control group (p < 0.05). The number of intercellular adhesion molecule-1 (ICAM-1)-positive vessels in the ischemic area of the anti-TNFα mAb-treated group was significantly less than that in the control group. 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Our study demonstrated that blocking TNFα reduced brain injury and attenuated ICAM-1 expression during transient cerebral ischemia.</description><subject>Biological and medical sciences</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNp1kc1KAzEUhYMoWKvvkIW4G00mmUyylGK1UHWjILgImcwdGp2fmsxYfSxfxGcytbU7QyBw-c65hxOEMCXnlKj8gsRD80wkVClJRJqSJE443UMjynOWZJl82kcjojKVcCWyQ3QUwktEFKFyhJ5n7cIVrnddi7sKP9xNv7-w6XtoB9NDwK6tjLc9fu_qoQFs2hLPJpe3CcXwsfQQwlro4g12AY2zuOmGALjwxrXH6KAydYCT7TtGj9Orh8lNMr-_jibzxDKR0sTytLQi5klLYIWkhKtKFEwWgnAgjCkjGCkFZFZSWQlW5KyyQjGQEniRGjZGZxvfpe_eBgi9bmIcqGvTQkyjqci4YJRGUG5A67sQPFR66V1j_KemRK_b1H9t6l2b-rfNKD3d7jDBmrryprUu7PQpY5ypPGJ8g626ugcfXuthBV4vwNT9Qv_3V-wHdVGECQ</recordid><startdate>19980622</startdate><enddate>19980622</enddate><creator>Yang, Guo-Yuan</creator><creator>Gong, Chao</creator><creator>Qin, Zhen</creator><creator>Ye, Wen</creator><creator>Mao, Ying</creator><creator>Bertz, A Lorris</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19980622</creationdate><title>Inhibition of TNFα attenuates infarct volume and ICAM-1 expression in ischemic mouse brain</title><author>Yang, Guo-Yuan ; Gong, Chao ; Qin, Zhen ; Ye, Wen ; Mao, Ying ; Bertz, A Lorris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3621-c42dc60902de3b81049f6b38b604e0339a630d6e5c818f63b73fc693e88e4b2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Biological and medical sciences</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Guo-Yuan</creatorcontrib><creatorcontrib>Gong, Chao</creatorcontrib><creatorcontrib>Qin, Zhen</creatorcontrib><creatorcontrib>Ye, Wen</creatorcontrib><creatorcontrib>Mao, Ying</creatorcontrib><creatorcontrib>Bertz, A Lorris</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Guo-Yuan</au><au>Gong, Chao</au><au>Qin, Zhen</au><au>Ye, Wen</au><au>Mao, Ying</au><au>Bertz, A Lorris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of TNFα attenuates infarct volume and ICAM-1 expression in ischemic mouse brain</atitle><jtitle>Neuroreport</jtitle><date>1998-06-22</date><risdate>1998</risdate><volume>9</volume><issue>9</issue><spage>2131</spage><epage>2134</epage><pages>2131-2134</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>THE purpose of our study was to determine whether inhibiting the action of tumor necrosis factor-α (TNFα) attenuates brain injury and reduces inflammatory responses in the mouse during ischemia and reperfusion. 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| subjects | Biological and medical sciences Medical sciences Neurology Vascular diseases and vascular malformations of the nervous system |
| title | Inhibition of TNFα attenuates infarct volume and ICAM-1 expression in ischemic mouse brain |
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