Transplacental Cocaine Exposure 1: A Rodent Model

To characterize the transplacental effects of cocaine on the developing brain, we have developed a mouse model of gestational cocaine exposure. Pharmacokinetic analysis revealed that cocaine and its metabolites (BE, BNE, and NC) were found in fetal brain and plasma at 30 and 120 min following SC adm...

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Veröffentlicht in:	Neurotoxicology and teratology 1998-05, Vol.20 (3), p.215-226
Hauptverfasser:	Wilkins, Aaron S., Genova, Lisa M., Posten, William, Kosofsky, Barry E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Attentional mechanisms Biological and medical sciences Body Weight - drug effects Brain - drug effects Brain - embryology Brain - metabolism Brain development Cocaine - analogs & derivatives Cocaine - blood Cocaine - metabolism Cocaine - pharmacokinetics Cocaine - toxicity Conditioning (Psychology) - drug effects Disease Models, Animal Drug addictions Drug Evaluation, Preclinical Female Male Maternal-Fetal Exchange Medical sciences Mice Mouse model Behavioral teratology Organ Size - drug effects Placenta - metabolism Pregnancy Prenatal cocaine Prenatal malnutrition Toxicology
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