A new conus peptide ligand for mammalian presynaptic Ca super(2+) channels

A new conus peptide ligand for mammalian presynaptic Ca super(2+) channels

Voltage-sensitive Ca super(2+) channels that control neurotransmitter release are blocked by omega -conotoxin ( omega -CgTx) GVIA from the marine snail Conus geographus , the most widely used inhibitor of neurotransmitter release. However, many mammalian synapses are omega -CgTx-GVIA insensitive. We...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 1992-01, Vol.9 (1), p.69-77
Hauptverfasser: Hillyard, DR, Monje, V D, Mintz, I M, Bean, B P, Nadasdi, L, Ramachandran, J, Miljanich, G, Azimi-Zoonooz, A, McIntosh, J M
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Sprache:eng
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Zusammenfassung:Voltage-sensitive Ca super(2+) channels that control neurotransmitter release are blocked by omega -conotoxin ( omega -CgTx) GVIA from the marine snail Conus geographus , the most widely used inhibitor of neurotransmitter release. However, many mammalian synapses are omega -CgTx-GVIA insensitive. We describe a new Conus peptide, omega -CgTx-MVIIC, that is an effective inhibitor of omega -CgTx-GVIA-resistant synaptic transmission. Ca super(2+) channel targets that are inhibited by omega -CgTx-MVIIC but not by omega -CgTx-GVIA include those mediating depolarization-induced super(45)Ca super(2+) uptake in rat synaptosome preparations, "P" currents in cerebellar Purkinje cells, and a subset of omega -CgTx-GVIA-resistant currents in CA1 hippocampal pyramidal cells.
ISSN:0896-6273