Stimulation of Human Polymorphonuclear Leukocytes by Consecutive Doses of Quartz and Interactions of Quartz with fMLP

The role of free intracellular calcium [Ca 2+] i was studied in the production of reactive oxygen metabolites (ROM) by human polymorphonuclear leukocytes (PMNL) after a single or two repeated doses of quartz. The significance of [Ca 2+] i, in the production of ROM was also studied after a dose of qu...

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Veröffentlicht in:	Toxicology and applied pharmacology 1993-02, Vol.118 (2), p.224-232
Hauptverfasser:	Tuomala, M., Hirvonen, M.R., Holopainen, M., Savolainen, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Calcium - metabolism Chemical and industrial products toxicology. Toxic occupational diseases Humans In Vitro Techniques Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) Medical sciences N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils - drug effects Neutrophils - metabolism Oxygen - metabolism Quartz - administration & dosage Quartz - toxicity Reactive Oxygen Species - metabolism Toxicology
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