Promotional activities of the non-genotoxic carcinogen bemitradine (SC-33643)

Bemitradine (SC‐33643), a diuretic antihypertensive agent, was studied for its carcinogenicity in a 2‐year bioassay in Charles River CD rats via dietary admix at dosages of 50, 150 and 450 mg kg−1 for up to 97 weeks (after which they were followed for eight additional weeks without treatment). Body...

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Veröffentlicht in:	Journal of applied toxicology 1992-06, Vol.12 (3), p.157-164
Hauptverfasser:	Gad, Shayne C., Burton, Earl, Chengelis, Christopher P., Levin, Stuart, Piper, Charles E., Oshiro, Yuki, Semler, David E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences carcinogenicity Carcinogens - toxicity CHO Cells Chromosome Aberrations Cricetinae Drug toxicity and drugs side effects treatment genotoxicity Hypoxanthine Phosphoribosyltransferase - genetics In Vitro Techniques Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - pathology Lymphoma - genetics Medical sciences Mice Micronucleus Tests Miscellaneous (drug allergy, mutagens, teratogens...) mutagenicity Mutagenicity Tests Mutagens - toxicity Pharmacology. Drug treatments promotion Pyrimidines - pharmacokinetics Pyrimidines - toxicity Rats Salmonella typhimurium - genetics Triazoles - pharmacokinetics Triazoles - toxicity
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