A Structural Role for Glutamine 214 in Human Thymidylate Synthase

Studies of the crystal structures of thymidylate synthase (TS) have revealed that a kink is present in β-sheets that form the core of the enzyme. The β-kink is proposed to serve as a “hinge” during conformational changes that occur in the enzyme after ligand binding at the active site. A residue in...

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