LY354740: a metabotropic glutamate receptor agonist which ameliorates symptoms of nicotine withdrawal in rats

LY354740 is a conformationally constrained analog of glutamate with high selectivity and nanomolar agonist activity at Group II metabotropic glutamate receptors (mGluRs). This orally active compound is a new drug candidate which is being developed for the treatment of anxiety. In this study, LY35474...

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Veröffentlicht in:	Neuropharmacology 1997-11, Vol.36 (11), p.1511-1516
Hauptverfasser:	Helton, D.R., Tizzano, J.P., Monn, J.A., Schoepp, D.D., Kallman, M.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Biological and medical sciences Bridged Bicyclo Compounds - therapeutic use Dose-Response Relationship, Drug Excitatory Amino Acid Agonists - therapeutic use Male Medical sciences Metabotropic glutamate receptors mGluRs Nicotine Nicotinic Agonists Rats Reflex, Startle - drug effects sensorimotor reactivity startle Stereoisomerism Substance Withdrawal Syndrome - drug therapy Substance Withdrawal Syndrome - psychology Tobacco, tobacco smoking Toxicology withdrawal
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