Synthesis and biological activity of 1-N-(4-(substituted)amidino and guanidino-2-hydroxybutyryl)kanamycins A and B

The synthesis and biological properties of 1-N-(4-(substituted)amidino and guanidino-2-hydroxybutyryl)kanamycins A and B are described. Reaction of 3,3'',6'-tri-N-tert-butoxycarbonyl-amikacin with an appropriate amidinating or guanidinating reagent and subsequent deblocking gave a ser...

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Veröffentlicht in:	Journal of antibiotics 1991, Vol.44 (6), p.646-658
Hauptverfasser:	YAMASAKI, TETSURO, NARITA, YUKIO, HOSHI, HIDEAKI, ABURAKI, SHIMPEI, KAMEI, HIDEO, NAITO, TAKAYUKI, KAWAGUCHI, HIROSHI
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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