Weekly Oral Azithromycin as Prophylaxis for Agents Causing Acute Respiratory Disease
Since the 1950s the U.S. military has used intramuscular injections of benzathine penicillin G (BPG) to control outbreaks of respiratory disease. In an effort to find an alternative prophylaxis, a randomized field trial was conducted among 1,016 male U.S. Marine trainee volunteers at high risk for r...
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| Veröffentlicht in: | Clinical infectious diseases 1998-01, Vol.26 (1), p.103-110 |
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| container_title | Clinical infectious diseases |
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| creator | Gray, Gregory C. McPhate, Dennis C. Leinonen, Maija Cassell, Gail H. Deperalta, Eduardo P. Putnam, Shannon D. Karcher, Jennifer A. Sawyer, Mark H. Laurila, Aino Connor, James D. |
| description | Since the 1950s the U.S. military has used intramuscular injections of benzathine penicillin G (BPG) to control outbreaks of respiratory disease. In an effort to find an alternative prophylaxis, a randomized field trial was conducted among 1,016 male U.S. Marine trainee volunteers at high risk for respiratory disease. Participants were evaluated for evidence of acute respiratory infection by serological tests on pretraining and posttraining sera (63 days apart). Oral azithromycin prophylaxis (500 mg/w) outperformed BPG, preventing infection from Streptococcus pyogenes (Efficacy [E] = 84%; 95% confidence interval [CI], 63%–93%), Streptococcus pneumoniae (E = 80%; 95% CI, 50%– 92%), Mycoplasma pneumoniae (E = 64%; 95% CI, 25%–83%), and Chlamydia pneumoniae (E = 58%; 95% CI, 15%–79%) in comparison with results in a no-treatment group. Azithromycin group subjects reported few side effects and less respiratory symptoms than the BPG and no-treatment groups. According to serological tests, oral azithromycin is an effective alternative prophylaxis to BPG for military populations. |
| doi_str_mv | 10.1086/516275 |
| format | Article |
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In an effort to find an alternative prophylaxis, a randomized field trial was conducted among 1,016 male U.S. Marine trainee volunteers at high risk for respiratory disease. Participants were evaluated for evidence of acute respiratory infection by serological tests on pretraining and posttraining sera (63 days apart). Oral azithromycin prophylaxis (500 mg/w) outperformed BPG, preventing infection from Streptococcus pyogenes (Efficacy [E] = 84%; 95% confidence interval [CI], 63%–93%), Streptococcus pneumoniae (E = 80%; 95% CI, 50%– 92%), Mycoplasma pneumoniae (E = 64%; 95% CI, 25%–83%), and Chlamydia pneumoniae (E = 58%; 95% CI, 15%–79%) in comparison with results in a no-treatment group. Azithromycin group subjects reported few side effects and less respiratory symptoms than the BPG and no-treatment groups. According to serological tests, oral azithromycin is an effective alternative prophylaxis to BPG for military populations.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/516275</identifier><identifier>PMID: 9455517</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Administration, Oral ; Adult ; Azithromycin - administration & dosage ; Azithromycin - adverse effects ; Azithromycin - therapeutic use ; Bacterial diseases ; Bacterial diseases of the respiratory system ; Biological and medical sciences ; Chlamydia pneumoniae ; Clinical Articles ; Epidemics ; Epidemiology ; Human bacterial diseases ; Humans ; Infections ; Infectious diseases ; Male ; Marine Corps ; Medical sciences ; Military recruitment ; Military training ; Mycoplasma pneumoniae ; Pathogens ; Penicillin ; Penicillin G Benzathine - therapeutic use ; Pharynx - microbiology ; Respiratory diseases ; Respiratory tract infections ; Respiratory Tract Infections - prevention & control ; Streptococcus - isolation & purification ; Streptococcus pneumoniae ; Streptococcus pyogenes</subject><ispartof>Clinical infectious diseases, 1998-01, Vol.26 (1), p.103-110</ispartof><rights>Copyright 1998 The University of Chicago</rights><rights>1998 by The University of Chicago 1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-fef169c8d0abcedda4426cd34911e00aa80631c7fd47412631ca74bb498544b03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4460295$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4460295$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,4009,27902,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2095807$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9455517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gray, Gregory C.</creatorcontrib><creatorcontrib>McPhate, Dennis C.</creatorcontrib><creatorcontrib>Leinonen, Maija</creatorcontrib><creatorcontrib>Cassell, Gail H.</creatorcontrib><creatorcontrib>Deperalta, Eduardo P.</creatorcontrib><creatorcontrib>Putnam, Shannon D.</creatorcontrib><creatorcontrib>Karcher, Jennifer A.</creatorcontrib><creatorcontrib>Sawyer, Mark H.</creatorcontrib><creatorcontrib>Laurila, Aino</creatorcontrib><creatorcontrib>Connor, James D.</creatorcontrib><title>Weekly Oral Azithromycin as Prophylaxis for Agents Causing Acute Respiratory Disease</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description>Since the 1950s the U.S. military has used intramuscular injections of benzathine penicillin G (BPG) to control outbreaks of respiratory disease. In an effort to find an alternative prophylaxis, a randomized field trial was conducted among 1,016 male U.S. Marine trainee volunteers at high risk for respiratory disease. Participants were evaluated for evidence of acute respiratory infection by serological tests on pretraining and posttraining sera (63 days apart). Oral azithromycin prophylaxis (500 mg/w) outperformed BPG, preventing infection from Streptococcus pyogenes (Efficacy [E] = 84%; 95% confidence interval [CI], 63%–93%), Streptococcus pneumoniae (E = 80%; 95% CI, 50%– 92%), Mycoplasma pneumoniae (E = 64%; 95% CI, 25%–83%), and Chlamydia pneumoniae (E = 58%; 95% CI, 15%–79%) in comparison with results in a no-treatment group. Azithromycin group subjects reported few side effects and less respiratory symptoms than the BPG and no-treatment groups. According to serological tests, oral azithromycin is an effective alternative prophylaxis to BPG for military populations.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Azithromycin - administration & dosage</subject><subject>Azithromycin - adverse effects</subject><subject>Azithromycin - therapeutic use</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the respiratory system</subject><subject>Biological and medical sciences</subject><subject>Chlamydia pneumoniae</subject><subject>Clinical Articles</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Marine Corps</subject><subject>Medical sciences</subject><subject>Military recruitment</subject><subject>Military training</subject><subject>Mycoplasma pneumoniae</subject><subject>Pathogens</subject><subject>Penicillin</subject><subject>Penicillin G Benzathine - therapeutic use</subject><subject>Pharynx - microbiology</subject><subject>Respiratory diseases</subject><subject>Respiratory tract infections</subject><subject>Respiratory Tract Infections - prevention & control</subject><subject>Streptococcus - isolation & purification</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pyogenes</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1L3EAUhgdRrNX2F1SYQuld7EzmI5PLZW27woJWLCu9GU4mEx3NJumcBIy_3l2ybK96dV54Ht4DLyEfObvgzOhvius0UwfkhCuRJVrl_HCTmTKJNMK8I-8Rnxjj3DB1TI5zqZTi2Qm5W3n_XI_0OkJNZ6-hf4ztenShoYD0Jrbd41jDS0BatZHOHnzTI53DgKF5oDM39J7eeuxChL6NI70M6AH9GTmqoEb_YXdPye8f3-_mi2R5_fNqPlsmTirRJ5WvuM6dKRkUzpclSJlqVwqZc-4ZAzBMC-6yqpSZ5Ok2QyaLQuZGSVkwcUq-Tr1dbP8OHnu7Duh8XUPj2wEt10oYpcQ_0cUWMfrKdjGsIY6WM7udz07zbcTzXeNQrH2513Z7bfiXHQd0UFcRGhdwr6UsV4Zttc-T1g7d_199mpwn3Gy3t6TULM23OJlwwN6_7DHEZ6szkSm7uP9jF6vLX4uVWNqVeAOwcpki</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Gray, Gregory C.</creator><creator>McPhate, Dennis C.</creator><creator>Leinonen, Maija</creator><creator>Cassell, Gail H.</creator><creator>Deperalta, Eduardo P.</creator><creator>Putnam, Shannon D.</creator><creator>Karcher, Jennifer A.</creator><creator>Sawyer, Mark H.</creator><creator>Laurila, Aino</creator><creator>Connor, James D.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>199801</creationdate><title>Weekly Oral Azithromycin as Prophylaxis for Agents Causing Acute Respiratory Disease</title><author>Gray, Gregory C. ; McPhate, Dennis C. ; Leinonen, Maija ; Cassell, Gail H. ; Deperalta, Eduardo P. ; Putnam, Shannon D. ; Karcher, Jennifer A. ; Sawyer, Mark H. ; Laurila, Aino ; Connor, James D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-fef169c8d0abcedda4426cd34911e00aa80631c7fd47412631ca74bb498544b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Azithromycin - administration & dosage</topic><topic>Azithromycin - adverse effects</topic><topic>Azithromycin - therapeutic use</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the respiratory system</topic><topic>Biological and medical sciences</topic><topic>Chlamydia pneumoniae</topic><topic>Clinical Articles</topic><topic>Epidemics</topic><topic>Epidemiology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Marine Corps</topic><topic>Medical sciences</topic><topic>Military recruitment</topic><topic>Military training</topic><topic>Mycoplasma pneumoniae</topic><topic>Pathogens</topic><topic>Penicillin</topic><topic>Penicillin G Benzathine - therapeutic use</topic><topic>Pharynx - microbiology</topic><topic>Respiratory diseases</topic><topic>Respiratory tract infections</topic><topic>Respiratory Tract Infections - prevention & control</topic><topic>Streptococcus - isolation & purification</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pyogenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gray, Gregory C.</creatorcontrib><creatorcontrib>McPhate, Dennis C.</creatorcontrib><creatorcontrib>Leinonen, Maija</creatorcontrib><creatorcontrib>Cassell, Gail H.</creatorcontrib><creatorcontrib>Deperalta, Eduardo P.</creatorcontrib><creatorcontrib>Putnam, Shannon D.</creatorcontrib><creatorcontrib>Karcher, Jennifer A.</creatorcontrib><creatorcontrib>Sawyer, Mark H.</creatorcontrib><creatorcontrib>Laurila, Aino</creatorcontrib><creatorcontrib>Connor, James D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gray, Gregory C.</au><au>McPhate, Dennis C.</au><au>Leinonen, Maija</au><au>Cassell, Gail H.</au><au>Deperalta, Eduardo P.</au><au>Putnam, Shannon D.</au><au>Karcher, Jennifer A.</au><au>Sawyer, Mark H.</au><au>Laurila, Aino</au><au>Connor, James D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Weekly Oral Azithromycin as Prophylaxis for Agents Causing Acute Respiratory Disease</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>1998-01</date><risdate>1998</risdate><volume>26</volume><issue>1</issue><spage>103</spage><epage>110</epage><pages>103-110</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract>Since the 1950s the U.S. military has used intramuscular injections of benzathine penicillin G (BPG) to control outbreaks of respiratory disease. In an effort to find an alternative prophylaxis, a randomized field trial was conducted among 1,016 male U.S. Marine trainee volunteers at high risk for respiratory disease. Participants were evaluated for evidence of acute respiratory infection by serological tests on pretraining and posttraining sera (63 days apart). Oral azithromycin prophylaxis (500 mg/w) outperformed BPG, preventing infection from Streptococcus pyogenes (Efficacy [E] = 84%; 95% confidence interval [CI], 63%–93%), Streptococcus pneumoniae (E = 80%; 95% CI, 50%– 92%), Mycoplasma pneumoniae (E = 64%; 95% CI, 25%–83%), and Chlamydia pneumoniae (E = 58%; 95% CI, 15%–79%) in comparison with results in a no-treatment group. Azithromycin group subjects reported few side effects and less respiratory symptoms than the BPG and no-treatment groups. According to serological tests, oral azithromycin is an effective alternative prophylaxis to BPG for military populations.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>9455517</pmid><doi>10.1086/516275</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 1998-01, Vol.26 (1), p.103-110 |
| issn | 1058-4838 1537-6591 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16538553 |
| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Administration, Oral Adult Azithromycin - administration & dosage Azithromycin - adverse effects Azithromycin - therapeutic use Bacterial diseases Bacterial diseases of the respiratory system Biological and medical sciences Chlamydia pneumoniae Clinical Articles Epidemics Epidemiology Human bacterial diseases Humans Infections Infectious diseases Male Marine Corps Medical sciences Military recruitment Military training Mycoplasma pneumoniae Pathogens Penicillin Penicillin G Benzathine - therapeutic use Pharynx - microbiology Respiratory diseases Respiratory tract infections Respiratory Tract Infections - prevention & control Streptococcus - isolation & purification Streptococcus pneumoniae Streptococcus pyogenes |
| title | Weekly Oral Azithromycin as Prophylaxis for Agents Causing Acute Respiratory Disease |
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