A New Paradigm for Neurotoxicity by FAD Mutants of βAPP: A Signaling Abnormality

We have demonstrated that normal βAPP 695 behave as a signaling receptor and indicated that point mutations at V642 create autoactive βAPP in signal transduction. Cellular expression of those familial Alzheimer’s disease-associated mutants causes neuronal cells to undergo apoptotic death; and proced...

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Veröffentlicht in:	Neurobiology of aging 1998, Vol.19 (1), p.S33-S38
1. Verfasser:	Nishimoto, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autoactivation Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Familial Alzheimer’s disease G o protein G βγ Medical sciences Neurology Signal transduction Transmembrane configuration βAP p
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