Modulation of organotin-induced apoptosis by the water pollutant methyl mercury in a human lymphoblastoid tumor cell line and a marine sponge
Apoptosis is a special form of cell death in which the cells actively participate in the process of dying. We found that the water pollutants tributyltin (> 1 μM) and methyl mercury (MeHg; at concentrations of > 3 μM) induce apoptosis in human T-lymphoblastoid CEM cells and in tissue of the ma...
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| Veröffentlicht in: | Marine ecology. Progress series (Halstenbek) 1993-01, Vol.93 (3), p.245-251 |
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| container_end_page | 251 |
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| container_issue | 3 |
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| container_title | Marine ecology. Progress series (Halstenbek) |
| container_volume | 93 |
| creator | Batel, Renato Bihari, Nevenka Rinkevich, Baruch Dapper, Jutta Schäcke, Heike Schröder, Heinz C. Müller, Werner E. G. |
| description | Apoptosis is a special form of cell death in which the cells actively participate in the process of dying. We found that the water pollutants tributyltin (> 1 μM) and methyl mercury (MeHg; at concentrations of > 3 μM) induce apoptosis in human T-lymphoblastoid CEM cells and in tissue of the marine sponge Geodia cydonium. At concentrations of > 5 μM, MeHg causes alkaline-labile sites in DNA of CEM cells. At the lower dose of 0.3 μM, MeHg abolishes the tributyltin-induced apoptosis in both CEM cells and sponge tissue. Incubation of sponge tissue with 3 μM of tributyltin induces not only apoptosis but also an increased expression of heat shock protein-70. |
| doi_str_mv | 10.3354/meps093245 |
| format | Article |
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Incubation of sponge tissue with 3 μM of tributyltin induces not only apoptosis but also an increased expression of heat shock protein-70.</description><subject>Apoptosis</subject><subject>Cell lines</subject><subject>Cubes</subject><subject>DNA</subject><subject>DNA fragmentation</subject><subject>Electrophoresis</subject><subject>Gels</subject><subject>Geodia cydonium</subject><subject>Marine</subject><subject>Sea water</subject><subject>Sponges</subject><subject>Water pollution</subject><issn>0171-8630</issn><issn>1616-1599</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNpFkMFq3TAQRUVIIS9pN9kHZtVFwanksSV7GULaBlKySddGlsd5CrLkSDLFH5F_jh8vtKvLwOFy5zB2Kfg1Yl19n2hOvMWyqk_YTkghC1G37SnbcaFE0UjkZ-w8pRfOhayU3LG332FYnM42eAgjhPisfcjWF9YPi6EB9BzmHJJN0K-Q9wR_daYIc3BuydpnmCjvV7dFNEtcwXrQsF8m7cGt07wPvdMpBztAXqYQwZBz4Kwn0H5rh0nHw5Hm4J_pM_s0apfoy0desD8_7p5ufxUPjz_vb28eCoNC5sKU_dA0SLxu6h4VR02kJKFBPggkRVL0imtuVK-0EKOpNhNmGJt2QCXaBi_Y12PvHMPrQil3k02HZdpTWFInZI1lWYsN_HYETQwpRRq7Odpt8toJ3h2Md_-Nb_DVEX7ZHo7_yLJqsFQl4jv_S4FZ</recordid><startdate>19930101</startdate><enddate>19930101</enddate><creator>Batel, Renato</creator><creator>Bihari, Nevenka</creator><creator>Rinkevich, Baruch</creator><creator>Dapper, Jutta</creator><creator>Schäcke, Heike</creator><creator>Schröder, Heinz C.</creator><creator>Müller, Werner E. 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| fulltext | fulltext |
| identifier | ISSN: 0171-8630 |
| ispartof | Marine ecology. Progress series (Halstenbek), 1993-01, Vol.93 (3), p.245-251 |
| issn | 0171-8630 1616-1599 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16532251 |
| source | Jstor Complete Legacy; Inter-Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Apoptosis Cell lines Cubes DNA DNA fragmentation Electrophoresis Gels Geodia cydonium Marine Sea water Sponges Water pollution |
| title | Modulation of organotin-induced apoptosis by the water pollutant methyl mercury in a human lymphoblastoid tumor cell line and a marine sponge |
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