Ins1(Cre) knock-in mice for beta cell-specific gene recombination

Pancreatic beta cells play a central role in the control of glucose homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues. Understanding the molecular mechanisms that control beta cell function and plasticity has critical implications for the pathophysiology and therapy...

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Veröffentlicht in:	Diabetologia 2015-03, Vol.58 (3), p.558-565
Hauptverfasser:	Thorens, Bernard, Tarussio, David, Maestro, Miguel Angel, Rovira, Meritxell, Heikkilä, Eija, Ferrer, Jorge
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Female Glucose Tolerance Test Insulin - genetics Insulin - metabolism Insulin-Secreting Cells - metabolism Integrases - genetics Integrases - metabolism Male Mice Mice, Mutant Strains
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