Absolute configuration of podophyllotoxone and its inhibitory activity against human prostate cancer cells

Podophyllotoxone (1) was isolated from the roots of Dysosma versipellis. The structure was determined by spectroscopic analysis in combination with single-crystal X-ray analysis. The absolute configuration of compound 1 was assigned based on the Flack parameter. It showed significant inhibitory acti...

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Veröffentlicht in:	Chinese journal of natural medicines 2015-01, Vol.13 (1), p.59-64
Hauptverfasser:	LI, Juan, FENG, Juan, LUO, Cheng, Herman, Ho-Yung Sung, JIANG, Ren-Wang
Format:	Artikel
Sprache:	eng
Schlagworte:	Absolute configuration Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Berberidaceae - chemistry Cell Line, Tumor Dose-Response Relationship, Drug G2 Phase - drug effects Humans Hydrogen Bonding - drug effects Male Molecular Conformation Molecular docking Molecular Docking Simulation Phytotherapy Plant Extracts - chemistry Plant Extracts - pharmacology Plant Roots - chemistry Podophyllotoxin - chemistry Podophyllotoxin - pharmacology Podophyllotoxone Polymerization Prostate cancer Prostatic Neoplasms - drug therapy Tubulin Tubulin - drug effects Tubulin Modulators - pharmacology
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