Ginkgo biloba extracts attenuate lipopolysaccharide-induced inflammatory responses in acute lung injury by inhibiting the COX-2 and NF-κB pathways

In the present study, we analyzed the role of Ginkgo biloba extract in lipopolysaccharide(LPS)-induced acute lung injury (ALI). ALI was induced in mice by intratracheal instillation of LPS. G. biloba extract (12 and 24 mg·kg−1) and dexamethasone (2 mg·kg−1), as a positive control, were given by i.p....

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Veröffentlicht in:	Chinese journal of natural medicines 2015-01, Vol.13 (1), p.52-58
Hauptverfasser:	YAO, Xin, CHEN, Nan, MA, Chun-Hua, TAO, Jing, BAO, Jian-An, Zong-Qi, CHENG, CHEN, Zu-Tao, MIAO, Li-Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - chemically induced Acute Lung Injury - drug therapy Acute Lung Injury - metabolism Animals Bronchoalveolar Lavage Fluid - cytology Cell Count Cyclooxygenase Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Enzyme-Linked Immunosorbent Assay Gene Expression - drug effects Ginkgo biloba - chemistry Ginkgo biloba extract Interleukin-1beta - analysis Interleukin-6 - analysis Lipopolysaccharide Lipopolysaccharides Lung - immunology Lung - pathology Male Mice Mice, Inbred BALB C Nuclear factor-κB Peroxidase - metabolism Phytotherapy Plant Extracts - pharmacology Pulmonary Edema Superoxide Dismutase - metabolism Transcription Factor RelA - genetics Transcription Factor RelA - metabolism Tumor Necrosis Factor-alpha - analysis
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