Expression of human bone morphogenic protein 7 in primary rabbit periosteal cells : potential utility in gene therapy for osteochondral repair

A commonly encountered problem in orthopedics is bone and cartilage tissue injury which heals incompletely or without full structural integrity. This necessitates development of improved methods for treatment of injuries which are not amenable to treatment using current therapies. An already large a...

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Veröffentlicht in:	Gene therapy 1998-08, Vol.5 (8), p.1098-1104
Hauptverfasser:	MASON, T. M, GRANDE, D. A, BARCIA, M, GRANT, R, PERGOLIZZI, R. G, BREITBART, A. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Animals Biological and medical sciences Biotechnology Bone grafts Bone Morphogenetic Protein 7 Bone morphogenetic proteins Bone Morphogenetic Proteins - genetics Bone remodeling Cartilage Cartilage - injuries Cell lines Cells, Cultured Explants Fractures, Bone - therapy Fractures, Cartilage Fundamental and applied biological sciences. Psychology Gene Expression Gene therapy Gene Transfer Techniques Genetic Therapy - methods Genetic Vectors Growth factors Health. Pharmaceutical industry Humans Hydroxyapatite Industrial applications and implications. Economical aspects Kidneys Male Mesenchyme NeoR gene Periosteum - cytology Periosteum - transplantation Polymerase chain reaction Polymers Proteins Rabbits Retroviridae RNA - analysis Stem cell transplantation Stem cells Tissue engineering Transforming Growth Factor beta β-Galactosidase
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