MycN and IFNγ cooperate in apoptosis of human neuroblastoma cells

Neuroblastomas undergo spontaneous regression at an unusually high rate. The mechanisms are not clear, but apoptosis may be involved. A large proportion of neuroblastomas is characterized by amplification of MYCN. Using human neuroblastoma cells harbouring tetracycline controlled expression of MYCN...

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Veröffentlicht in:	Oncogene 1998-07, Vol.17 (3), p.339-346
Hauptverfasser:	LUTZ, W, FULDA, S, JEREMIAS, I, DEBATIN, K.-M, SCHWAB, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bax protein Biological and medical sciences Caspase CD95 antigen Cell death Cell physiology Cell surface Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA fragmentation Fundamental and applied biological sciences. Psychology Gene expression Molecular and cellular biology mRNA Neuroblastoma Neuroblastoma cells Tumor necrosis factor-α γ-Interferon
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