Cytotoxic effect of ricin A-chain conjugates containing monoclonal antibodies against human erythroid cells

Selective elimination of human erythroblastoid cells by the conjugate of the A-chain of a plant toxin ricin (R A) and monoclonal antibody (MAb) HAE9 (IgM) directed against human erythroblast antigen (Ag-Eb) has been demonstrated. In comparative experiments, MAb HAE3 (IgM) against human glycophorin-A...

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Veröffentlicht in:	International journal of immunopharmacology 1993-02, Vol.15 (2), p.229-235
Hauptverfasser:	Tonevitsky, A.G., Agapov, I.I., Ershova, G.V., Sarma, T., Toptygin, A.Yu, Mechetner, E.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - metabolism Binding Sites Cell Death - drug effects Cell Line Erythroblasts - drug effects Erythroblasts - immunology Erythroblasts - metabolism Humans Immunotoxins - metabolism Immunotoxins - pharmacology Ricin - metabolism Ricin - pharmacology
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