Are DNA-based vaccines useful for protection against secreted bacterial toxins? Tetanus toxin test case

Polypeptide and DNA vaccine alternatives to the conventional tetanus toxoid were compared. Mouse immunizations with plasmid DNA that encoded the tetanus toxin C fragment polypeptide induced consistently lower antibody responses than direct immunization with the C fragment polypeptide or toxoid, yet...

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Veröffentlicht in:	Vaccine 1998-05, Vol.16 (9), p.1029-1038
Hauptverfasser:	Saikh, Kamal U., Sesno, Julie, Brandler, Patricia, Ulrich, Robert G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Bacterial - biosynthesis Antigen Presentation Antigens, Bacterial - genetics Applied microbiology Biological and medical sciences Cell Line Clostridium tetani - genetics Clostridium tetani - immunology cytotoxic T-cells Cytotoxicity, Immunologic DNA vaccines Female Fundamental and applied biological sciences. Psychology Lymphocyte Activation Mice Mice, Inbred BALB C Microbiology Peptide Fragments - immunology Peptide Fragments - pharmacology Plasmids - genetics T-Lymphocytes - immunology Tetanus - immunology Tetanus - prevention & control tetanus toxin Tetanus Toxin - genetics Tetanus Toxin - immunology Tetanus Toxin - pharmacology Tetanus Toxoid - genetics Tetanus Toxoid - immunology Tetanus Toxoid - pharmacology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - genetics Vaccines, DNA - immunology Vaccines, DNA - pharmacology
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