A novel role for the peritrophic matrix in protecting Leishmania from the hydrolytic activities of the sand fly midgut

The role of the peritrophic matrix (PM) in the development of Leishmania major infections in a natural vector, Phlebotomus papatasi, was investigated by addition of exogenous chitinase to the bloodmeal, which completely blocked PM formation. Surprisingly, the absence of the PM was associated with th...

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Veröffentlicht in:	Parasitology 1997-10, Vol.115 (4), p.359-369
Hauptverfasser:	PIMENTA, P. F. P., MODI, G. B., PEREIRA, S. T., SHAHABUDDIN, M., SACKS, D. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - analogs & derivatives Acetylglucosamine - pharmacology allosamidin Animals Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences chitinase Chitinases - antagonists & inhibitors Chitinases - pharmacology Digestive System - anatomy & histology Digestive System - metabolism Digestive System - parasitology Eating Fundamental and applied biological sciences. Psychology Hydrolysis Insect Vectors - anatomy & histology Insect Vectors - parasitology Leishmania Leishmania major - drug effects peritrophic membrane Phlebotomus - anatomy & histology Phlebotomus - parasitology Protozoa sand fly Trisaccharides - pharmacology Trypsin - pharmacology
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