Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene

Recently, the potential utility of the BCP motif, as a contemporary lead optimization tactic, has generated substantial interest in medicinal chemistry. To facilitate this inquisitiveness, the concomitant development of efficient synthetic protocols is crucial. The following work discloses a new, ex...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-02, Vol.51 (15), p.3139-3142
Hauptverfasser:	Thirumoorthi, Navanita T, Jia Shen, Chew, Adsool, Vikrant A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Amines - chemistry Benzene - chemistry Bridged Bicyclo Compounds - chemistry
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description	Recently, the potential utility of the BCP motif, as a contemporary lead optimization tactic, has generated substantial interest in medicinal chemistry. To facilitate this inquisitiveness, the concomitant development of efficient synthetic protocols is crucial. The following work discloses a new, expedient and versatile approach to one such potentially useful BCP derivative.
doi_str_mv	10.1039/c4cc09655j
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source	MEDLINE; Royal Society Of Chemistry Journals; Alma/SFX Local Collection
subjects	Alkylation Amines - chemistry Benzene - chemistry Bridged Bicyclo Compounds - chemistry
title	Expedient synthesis of 3-phenylbicyclo[1.1.1]pentan-1-amine via metal-free homolytic aromatic alkylation of benzene
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