An Efficient and Highly Diastereoselective Synthesis of GSK1265744, a Potent HIV Integrase Inhibitor

A novel synthesis of GSK1265744, a potent HIV integrase inhibitor, is described. The synthesis is highlighted by an efficient construction of the densely functionalized pyridinone core as well as a highly diastereoselective formation of the acyl oxazolidine moiety. The latter exploits the target mol...

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Veröffentlicht in:	Organic letters 2015-02, Vol.17 (3), p.564-567
Hauptverfasser:	Wang, Huan, Kowalski, Matthew D, Lakdawala, Ami S, Vogt, Frederick G, Wu, Lianming
Format:	Artikel
Sprache:	eng
Schlagworte:	Chelating Agents - chemistry Chelating Agents - metabolism HIV Integrase Inhibitors - chemical synthesis HIV Integrase Inhibitors - chemistry HIV Integrase Inhibitors - pharmacology Magnesium - chemistry Magnesium - metabolism Molecular Structure Pyridones - chemical synthesis Pyridones - chemistry Pyridones - pharmacology Stereoisomerism Structure-Activity Relationship
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