Efficient 11C‑Carbonylation of Isolated Aryl Palladium Complexes for PET: Application to Challenging Radiopharmaceutical Synthesis

We describe the successful implementation of palladium-aryl oxidative addition complexes as stoichiometric reagents in carbonylation reactions with 11CO to produce structurally challenging, pharmaceutically relevant compounds. This method enables the first 11C-carbonyl labeling of an approved PET tr...

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Veröffentlicht in:	Journal of the American Chemical Society 2015-02, Vol.137 (4), p.1548-1555
Hauptverfasser:	Andersen, Thomas L, Friis, Stig D, Audrain, Hélène, Nordeman, Patrik, Antoni, Gunnar, Skrydstrup, Troels
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzamides - chemistry Carbon Radioisotopes - chemistry Coordination Complexes - chemistry Models, Molecular Palladium - chemistry Phthalazines - chemistry Piperazines - chemistry Positron-Emission Tomography Raclopride - chemistry Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - chemistry
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