A study on the inhibition of dihydrofolate reductase (DHFR) from Escherichia coli by gold(i) phosphane compounds. X-ray crystal structures of (4,5-dichloro-1H-imidazolate-1-yl)-triphenylphosphane-gold(i) and (4,5-dicyano-1H-imidazolate-1-yl)-triphenylphosphane-gold(i)

An unprecedented study on the inhibitory activities of a class of phosphane gold(i) complexes on E. coli dihydrofolate reductase (DHFR) is reported. The gold(i) complexes considered in this work consist of azolate or chloride ligands and phosphane as co-ligands. The ligands have been functionalized...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2015-02, Vol.44 (7), p.3043-3056
Hauptverfasser:	Galassi, Rossana, Oumarou, Camille Simon, Burini, Alfredo, Dolmella, Alessandro, Micozzi, Daniela, Vincenzetti, Silvia, Pucciarelli, Stefania
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray Escherichia coli - enzymology Escherichia coli Proteins - antagonists & inhibitors Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Folic Acid Antagonists - chemistry Folic Acid Antagonists - metabolism Folic Acid Antagonists - pharmacology Gold - chemistry Gold - metabolism Gold - pharmacology Phosphines - chemistry Phosphines - metabolism Phosphines - pharmacology Tetrahydrofolate Dehydrogenase - chemistry Tetrahydrofolate Dehydrogenase - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!