Engineering Controllable Architecture in Matrigel for 3D Cell Alignment

We report a microfluidic approach to impart alignment in ECM components in 3D hydrogels by continuously applying fluid flow across the bulk gel during the gelation process. The microfluidic device where each channel can be independently filled was tilted at 90° to generate continuous flow across the...

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Veröffentlicht in:	ACS applied materials & interfaces 2015-02, Vol.7 (4), p.2183-2188
Hauptverfasser:	Jang, Jae Myung, Tran, Si-Hoai-Trung, Na, Sang Cheol, Jeon, Noo Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Culture Techniques - instrumentation Cell Culture Techniques - methods Cell Proliferation Cells, Cultured Collagen - chemical synthesis Collagen - chemistry Drug Combinations Extracellular Matrix - metabolism Laminin - chemical synthesis Laminin - chemistry Mice Microfluidic Analytical Techniques - instrumentation Microfluidic Analytical Techniques - methods Neurons - chemistry Neurons - cytology Proteoglycans - chemical synthesis Proteoglycans - chemistry Rats Stem Cells - chemistry Stem Cells - cytology
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