Effectiveness and safety of selected bone marrow stem cells on left ventricular function in patients with acute myocardial infarction: A meta-analysis of randomized controlled trials
Abstract Background Concerns regarding the use of selected bone marrow stem cells (BMSCs) in the field of cardiac repair after acute ischemic events have been raised. The current meta-analysis aimed to assess the efficacy and safety of selected BMSC transplantation in patients with acute myocardial...
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| Veröffentlicht in: | International journal of cardiology 2014-12, Vol.177 (3), p.764-770 |
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| container_title | International journal of cardiology |
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| creator | Liu, Bei Duan, Chong-Yang Luo, Cheng-Feng Ou, Cai-Wen Sun, Kan Wu, Zhi-Ye Huang, He Cheng, Chuan-Fang Li, Yun-Peng Chen, Min-Sheng |
| description | Abstract Background Concerns regarding the use of selected bone marrow stem cells (BMSCs) in the field of cardiac repair after acute ischemic events have been raised. The current meta-analysis aimed to assess the efficacy and safety of selected BMSC transplantation in patients with acute myocardial infarction (AMI) based on published randomized controlled trials (RCTs). Methods A systematic literature search of PubMed, Ovid LWW, BIOSIS Previews, and the Cochrane library from 1990 to 2014 was conducted. Results from RCTs involving subjects with AMI receiving selected BMSC therapy and followed up for at least 6 months were pooled. Results Eight trials with a total of 262 participants were included. Data were analyzed using a random effects model. Overall, selected BMSC therapy improved left ventricular ejection fraction (LVEF) by 3.17% (95% confidence interval [CI] 0.57–5.76, P = 0.02), compared with the controls. There were trends toward reduced left ventricular end-systolic volume (LVESV) and fewer major adverse cardiac events (MACEs). Subgroup analysis revealed a significant difference in LVEF in favor of selected BMSC therapy with bone marrow mesenchymal stem cells (BMMSCs) as the cell type. Conclusions Transplantation of selected BMSCs for patients with AMI is safe and induces a significant increase in LVEF with a limited impact on left ventricular remodeling. |
| doi_str_mv | 10.1016/j.ijcard.2014.11.005 |
| format | Article |
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The current meta-analysis aimed to assess the efficacy and safety of selected BMSC transplantation in patients with acute myocardial infarction (AMI) based on published randomized controlled trials (RCTs). Methods A systematic literature search of PubMed, Ovid LWW, BIOSIS Previews, and the Cochrane library from 1990 to 2014 was conducted. Results from RCTs involving subjects with AMI receiving selected BMSC therapy and followed up for at least 6 months were pooled. Results Eight trials with a total of 262 participants were included. Data were analyzed using a random effects model. Overall, selected BMSC therapy improved left ventricular ejection fraction (LVEF) by 3.17% (95% confidence interval [CI] 0.57–5.76, P = 0.02), compared with the controls. There were trends toward reduced left ventricular end-systolic volume (LVESV) and fewer major adverse cardiac events (MACEs). Subgroup analysis revealed a significant difference in LVEF in favor of selected BMSC therapy with bone marrow mesenchymal stem cells (BMMSCs) as the cell type. Conclusions Transplantation of selected BMSCs for patients with AMI is safe and induces a significant increase in LVEF with a limited impact on left ventricular remodeling.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2014.11.005</identifier><identifier>PMID: 25465825</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Acute myocardial infarction ; Biological and medical sciences ; Bone Marrow Transplantation - methods ; Cardiology. Vascular system ; Cardiovascular ; Clinical Trials as Topic - methods ; Coronary heart disease ; Heart ; Humans ; Medical sciences ; Meta-analysis ; Myocardial Infarction - diagnosis ; Myocardial Infarction - physiopathology ; Myocardial Infarction - therapy ; Myocarditis. Cardiomyopathies ; Randomized controlled trials ; Selected bone marrow stem cells ; Stroke Volume - physiology ; Treatment Outcome ; Ventricular Function, Left - physiology</subject><ispartof>International journal of cardiology, 2014-12, Vol.177 (3), p.764-770</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2014 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-4775e08d57fba8198c6e7aee95c8a6aeced3e6fb07640d69ae89cee0f79f27823</citedby><cites>FETCH-LOGICAL-c447t-4775e08d57fba8198c6e7aee95c8a6aeced3e6fb07640d69ae89cee0f79f27823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijcard.2014.11.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=29034216$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25465825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Bei</creatorcontrib><creatorcontrib>Duan, Chong-Yang</creatorcontrib><creatorcontrib>Luo, Cheng-Feng</creatorcontrib><creatorcontrib>Ou, Cai-Wen</creatorcontrib><creatorcontrib>Sun, Kan</creatorcontrib><creatorcontrib>Wu, Zhi-Ye</creatorcontrib><creatorcontrib>Huang, He</creatorcontrib><creatorcontrib>Cheng, Chuan-Fang</creatorcontrib><creatorcontrib>Li, Yun-Peng</creatorcontrib><creatorcontrib>Chen, Min-Sheng</creatorcontrib><title>Effectiveness and safety of selected bone marrow stem cells on left ventricular function in patients with acute myocardial infarction: A meta-analysis of randomized controlled trials</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Abstract Background Concerns regarding the use of selected bone marrow stem cells (BMSCs) in the field of cardiac repair after acute ischemic events have been raised. The current meta-analysis aimed to assess the efficacy and safety of selected BMSC transplantation in patients with acute myocardial infarction (AMI) based on published randomized controlled trials (RCTs). Methods A systematic literature search of PubMed, Ovid LWW, BIOSIS Previews, and the Cochrane library from 1990 to 2014 was conducted. Results from RCTs involving subjects with AMI receiving selected BMSC therapy and followed up for at least 6 months were pooled. Results Eight trials with a total of 262 participants were included. Data were analyzed using a random effects model. Overall, selected BMSC therapy improved left ventricular ejection fraction (LVEF) by 3.17% (95% confidence interval [CI] 0.57–5.76, P = 0.02), compared with the controls. There were trends toward reduced left ventricular end-systolic volume (LVESV) and fewer major adverse cardiac events (MACEs). Subgroup analysis revealed a significant difference in LVEF in favor of selected BMSC therapy with bone marrow mesenchymal stem cells (BMMSCs) as the cell type. Conclusions Transplantation of selected BMSCs for patients with AMI is safe and induces a significant increase in LVEF with a limited impact on left ventricular remodeling.</description><subject>Acute myocardial infarction</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation - methods</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Clinical Trials as Topic - methods</subject><subject>Coronary heart disease</subject><subject>Heart</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Meta-analysis</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - therapy</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Randomized controlled trials</subject><subject>Selected bone marrow stem cells</subject><subject>Stroke Volume - physiology</subject><subject>Treatment Outcome</subject><subject>Ventricular Function, Left - physiology</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFu1DAQhiMEotvCGyDkCxKXBDvrxAkHpKoqBakSB-BseZ2xcHDixeO0Wh6M52PCLiBx4TSW5pv5Z-Z3UTwTvBJctK_Gyo_WpKGquZCVEBXnzYNiIzolS6Ea-bDYEKbKplbbs-IcceScy77vHhdndSPbpqubTfHj2jmw2d_BDIjMzAND4yAfWHQMIVAOBraLM7DJpBTvGWaYmIUQkMWZBXCZUXFO3i7BJOaWmdpRxs9sb7KnFLJ7n78wY5dMXQ5xndqbQIQz6Rf8ml2yCbIpzWzCAT2u6omGiZP_Tvo2kkAMgZ4kZAI-KR45CvD0FC-Kz2-vP129K28_3Ly_urwtrZQql1KpBng3NMrtTCf6zragDEDf2M60BiwMW2jdjqtW8qHtDXS9BeBO9a5WXb29KF4e--5T_LYAZj15XJc3M8QFtWibWrZc8o5QeURtiogJnN4nTzc7aMH16pge9dExvTqmhdDkGJU9PyksuwmGP0W_LSLgxQkwaE1wdBbr8S_X862sRUvcmyMHdI87D0mjpevTij6Ri3qI_n-T_NvABj970vwKB8AxLoncoZ011prrj-vvWj-XkLwWUvHtT7e-0Fg</recordid><startdate>20141220</startdate><enddate>20141220</enddate><creator>Liu, Bei</creator><creator>Duan, Chong-Yang</creator><creator>Luo, Cheng-Feng</creator><creator>Ou, Cai-Wen</creator><creator>Sun, Kan</creator><creator>Wu, Zhi-Ye</creator><creator>Huang, He</creator><creator>Cheng, Chuan-Fang</creator><creator>Li, Yun-Peng</creator><creator>Chen, Min-Sheng</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141220</creationdate><title>Effectiveness and safety of selected bone marrow stem cells on left ventricular function in patients with acute myocardial infarction: A meta-analysis of randomized controlled trials</title><author>Liu, Bei ; Duan, Chong-Yang ; Luo, Cheng-Feng ; Ou, Cai-Wen ; Sun, Kan ; Wu, Zhi-Ye ; Huang, He ; Cheng, Chuan-Fang ; Li, Yun-Peng ; Chen, Min-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-4775e08d57fba8198c6e7aee95c8a6aeced3e6fb07640d69ae89cee0f79f27823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acute myocardial infarction</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Transplantation - methods</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Clinical Trials as Topic - methods</topic><topic>Coronary heart disease</topic><topic>Heart</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Meta-analysis</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Infarction - therapy</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Randomized controlled trials</topic><topic>Selected bone marrow stem cells</topic><topic>Stroke Volume - physiology</topic><topic>Treatment Outcome</topic><topic>Ventricular Function, Left - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Bei</creatorcontrib><creatorcontrib>Duan, Chong-Yang</creatorcontrib><creatorcontrib>Luo, Cheng-Feng</creatorcontrib><creatorcontrib>Ou, Cai-Wen</creatorcontrib><creatorcontrib>Sun, Kan</creatorcontrib><creatorcontrib>Wu, Zhi-Ye</creatorcontrib><creatorcontrib>Huang, He</creatorcontrib><creatorcontrib>Cheng, Chuan-Fang</creatorcontrib><creatorcontrib>Li, Yun-Peng</creatorcontrib><creatorcontrib>Chen, Min-Sheng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Bei</au><au>Duan, Chong-Yang</au><au>Luo, Cheng-Feng</au><au>Ou, Cai-Wen</au><au>Sun, Kan</au><au>Wu, Zhi-Ye</au><au>Huang, He</au><au>Cheng, Chuan-Fang</au><au>Li, Yun-Peng</au><au>Chen, Min-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness and safety of selected bone marrow stem cells on left ventricular function in patients with acute myocardial infarction: A meta-analysis of randomized controlled trials</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2014-12-20</date><risdate>2014</risdate><volume>177</volume><issue>3</issue><spage>764</spage><epage>770</epage><pages>764-770</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract>Abstract Background Concerns regarding the use of selected bone marrow stem cells (BMSCs) in the field of cardiac repair after acute ischemic events have been raised. The current meta-analysis aimed to assess the efficacy and safety of selected BMSC transplantation in patients with acute myocardial infarction (AMI) based on published randomized controlled trials (RCTs). Methods A systematic literature search of PubMed, Ovid LWW, BIOSIS Previews, and the Cochrane library from 1990 to 2014 was conducted. Results from RCTs involving subjects with AMI receiving selected BMSC therapy and followed up for at least 6 months were pooled. Results Eight trials with a total of 262 participants were included. Data were analyzed using a random effects model. Overall, selected BMSC therapy improved left ventricular ejection fraction (LVEF) by 3.17% (95% confidence interval [CI] 0.57–5.76, P = 0.02), compared with the controls. There were trends toward reduced left ventricular end-systolic volume (LVESV) and fewer major adverse cardiac events (MACEs). Subgroup analysis revealed a significant difference in LVEF in favor of selected BMSC therapy with bone marrow mesenchymal stem cells (BMMSCs) as the cell type. Conclusions Transplantation of selected BMSCs for patients with AMI is safe and induces a significant increase in LVEF with a limited impact on left ventricular remodeling.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>25465825</pmid><doi>10.1016/j.ijcard.2014.11.005</doi><tpages>7</tpages></addata></record> |
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| subjects | Acute myocardial infarction Biological and medical sciences Bone Marrow Transplantation - methods Cardiology. Vascular system Cardiovascular Clinical Trials as Topic - methods Coronary heart disease Heart Humans Medical sciences Meta-analysis Myocardial Infarction - diagnosis Myocardial Infarction - physiopathology Myocardial Infarction - therapy Myocarditis. Cardiomyopathies Randomized controlled trials Selected bone marrow stem cells Stroke Volume - physiology Treatment Outcome Ventricular Function, Left - physiology |
| title | Effectiveness and safety of selected bone marrow stem cells on left ventricular function in patients with acute myocardial infarction: A meta-analysis of randomized controlled trials |
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