Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells

Significance In the endoplasmic reticulum (ER), N-glycans on glycoproteins play important roles in dictating the folding status of proteins by a sophisticated N-glycan–dependent protein quality control machinery. In this study we identified the dysregulation of ER-associated degradation (ERAD) in ce...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-02, Vol.112 (5), p.1398-1403
Hauptverfasser:	Huang, Chengcheng, Harada, Yoichiro, Hosomi, Akira, Masahara-Negishi, Yuki, Seino, Junichi, Fujihira, Haruhiko, Funakoshi, Yoko, Suzuki, Takehiro, Dohmae, Naoshi, Suzuki, Tadashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - metabolism Animals Biological Sciences Cells, Cultured endoplasmic reticulum Endoplasmic Reticulum - metabolism genes genetic disorders glycoproteins humans Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase - metabolism Mice Mutation Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase - genetics Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase - metabolism protein aggregates quality control Radioimmunoprecipitation Assay solubility
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