A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma

Distinct molecular subgroups of medulloblastoma, including hedgehog (Hh) pathway-activated disease, have been reported. We identified and clinically validated a five-gene Hh signature assay that can be used to preselect patients with Hh pathway-activated medulloblastoma. Gene characteristics of the...

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Veröffentlicht in:	Clinical cancer research 2015-02, Vol.21 (3), p.585-593
Hauptverfasser:	Shou, Yaping, Robinson, Douglas M, Amakye, Dereck D, Rose, Kristine L, Cho, Yoon-Jae, Ligon, Keith L, Sharp, Thad, Haider, Asifa S, Bandaru, Raj, Ando, Yuichi, Geoerger, Birgit, Doz, François, Ashley, David M, Hargrave, Darren R, Casanova, Michela, Tawbi, Hussein A, Rodon, Jordi, Thomas, Anne L, Mita, Alain C, MacDonald, Tobey J, Kieran, Mark W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biphenyl Compounds - pharmacology Biphenyl Compounds - therapeutic use Cerebellar Neoplasms - drug therapy Cerebellar Neoplasms - genetics Cerebellar Neoplasms - metabolism Child Child, Preschool Computational Biology Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Hedgehog Proteins - antagonists & inhibitors Hedgehog Proteins - metabolism Humans Infant Medulloblastoma - drug therapy Medulloblastoma - genetics Medulloblastoma - metabolism Models, Biological Patient Selection Prognosis Pyridines - pharmacology Pyridines - therapeutic use Reproducibility of Results Signal Transduction - drug effects Transcriptome Treatment Outcome
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