Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7

Gremlin (Grem1) is a member of the DAN family of secreted bone morphogenetic protein (BMP) antagonists. Bone morphogenetic protein-7 (BMP-7) mediates protective effects during renal fibrosis associated with diabetes and other renal diseases. The pathogenic mechanism of Grem1 during diabetic nephropa...

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Veröffentlicht in:	Biochemical journal 2015-02, Vol.466 (1), p.55-68
Hauptverfasser:	Church, Rachel H, Krishnakumar, Arjun, Urbanek, Annika, Geschwindner, Stefan, Meneely, Julie, Bianchi, Alessandro, Basta, Barbro, Monaghan, Sean, Elliot, Christopher, Strömstedt, Maria, Ferguson, Neil, Martin, Finian, Brazil, Derek P
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Morphogenetic Protein 2 - genetics Bone Morphogenetic Protein 2 - metabolism Bone Morphogenetic Protein 4 - genetics Bone Morphogenetic Protein 4 - metabolism Bone Morphogenetic Protein 7 - genetics Bone Morphogenetic Protein 7 - metabolism Cell Line Epithelial Cells - cytology Epithelial Cells - metabolism Gene Expression Regulation HEK293 Cells Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - metabolism Phosphorylation Protein Binding Signal Transduction Smad1 Protein - genetics Smad1 Protein - metabolism Smad5 Protein - genetics Smad5 Protein - metabolism Smad8 Protein - genetics Smad8 Protein - metabolism Surface Plasmon Resonance
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