Is There an Association between Cerebral Microbleeds and Leukoaraiosis?
Purpose Cerebral microbleeds (CMBs) are small dot-like lesions appearing as hyposignals on gradient echo (GRE) T2* magnetic resonance (MR) sequences, whereas the leukoaraiosis (LA) indicates the presence of patchy areas of hypersignal on fluid-attenuated inversion recovery (FLAIR) MR sequences in th...
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| Veröffentlicht in: | Journal of stroke and cerebrovascular diseases 2015-02, Vol.24 (2), p.284-289 |
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| creator | Saba, Luca, MD Raz, Eytan, MD Bassareo, Pier P., MD di Martino, Michele, MD de Cecco, Carlo Nicola, MD Mercuro, Giuseppe, MD Grassi, Roberto, MD Suri, Jasjit S., MD, PhD Piga, Mario, MD |
| description | Purpose Cerebral microbleeds (CMBs) are small dot-like lesions appearing as hyposignals on gradient echo (GRE) T2* magnetic resonance (MR) sequences, whereas the leukoaraiosis (LA) indicates the presence of patchy areas of hypersignal on fluid-attenuated inversion recovery (FLAIR) MR sequences in the periventricular white matter. The purpose of this work was to evaluate the association between LA and CMBs. Material and Methods Eighty-five consecutive (men 55; median age 64 years) patients were retrospectively analyzed using a 1.5 T system; CMBs were studied using a T2*-weighted GRE sequence and classified as absent (grade 1), mild (grade 2; total number of microbleeds, 1-2), moderate (grade 3; total number of microbleeds, 3-10), and severe (grade 4; total number of microbleeds, >10). LA was assessed with FLAIR MR sequences and was graded based on the European Task Force on Age-Related White Matter Changes as follows: 1 (no lesions), 2 (focal lesions > 5 mm), 3 (early confluent lesions), and 4 (diffuse involvement of an entire brain region). Results We considered 170 cerebral hemispheres. The prevalence of CMBs was 24.7% (42 of 170), whereas the prevalence of LA was 27.1% (46 of 170). A statistically significant correlation was observed between LA and CMBs (correlation rho = .495, P value = .001). Multiple logistic regression analysis showed an association between CMBs and cerebrovascular symptoms ( P = .0023). Conclusion Results of this study suggest an association between CMBs and LA. Moreover, we found that LA is associated with the presence of cerebrovascular symptoms. |
| doi_str_mv | 10.1016/j.jstrokecerebrovasdis.2014.07.035 |
| format | Article |
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The purpose of this work was to evaluate the association between LA and CMBs. Material and Methods Eighty-five consecutive (men 55; median age 64 years) patients were retrospectively analyzed using a 1.5 T system; CMBs were studied using a T2*-weighted GRE sequence and classified as absent (grade 1), mild (grade 2; total number of microbleeds, 1-2), moderate (grade 3; total number of microbleeds, 3-10), and severe (grade 4; total number of microbleeds, >10). LA was assessed with FLAIR MR sequences and was graded based on the European Task Force on Age-Related White Matter Changes as follows: 1 (no lesions), 2 (focal lesions > 5 mm), 3 (early confluent lesions), and 4 (diffuse involvement of an entire brain region). Results We considered 170 cerebral hemispheres. The prevalence of CMBs was 24.7% (42 of 170), whereas the prevalence of LA was 27.1% (46 of 170). A statistically significant correlation was observed between LA and CMBs (correlation rho = .495, P value = .001). Multiple logistic regression analysis showed an association between CMBs and cerebrovascular symptoms ( P = .0023). Conclusion Results of this study suggest an association between CMBs and LA. Moreover, we found that LA is associated with the presence of cerebrovascular symptoms.</description><identifier>ISSN: 1052-3057</identifier><identifier>EISSN: 1532-8511</identifier><identifier>DOI: 10.1016/j.jstrokecerebrovasdis.2014.07.035</identifier><identifier>PMID: 25440349</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Brain - pathology ; Cardiovascular ; Cerebral Hemorrhage - epidemiology ; Cerebral Hemorrhage - pathology ; Cerebral microbleeds ; CMB ; Comorbidity ; Female ; Humans ; imaging ; leukoaraiosis ; Leukoaraiosis - epidemiology ; Leukoaraiosis - pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; MRI ; Neurology ; Prevalence ; Retrospective Studies</subject><ispartof>Journal of stroke and cerebrovascular diseases, 2015-02, Vol.24 (2), p.284-289</ispartof><rights>National Stroke Association</rights><rights>2015 National Stroke Association</rights><rights>Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-2abe047b470d344adf752d08d40aa2147f0b8fc39f3f2f9b8e1495b5372fe33b3</citedby><cites>FETCH-LOGICAL-c459t-2abe047b470d344adf752d08d40aa2147f0b8fc39f3f2f9b8e1495b5372fe33b3</cites><orcidid>0000-0003-2870-3771</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2014.07.035$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25440349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saba, Luca, MD</creatorcontrib><creatorcontrib>Raz, Eytan, MD</creatorcontrib><creatorcontrib>Bassareo, Pier P., MD</creatorcontrib><creatorcontrib>di Martino, Michele, MD</creatorcontrib><creatorcontrib>de Cecco, Carlo Nicola, MD</creatorcontrib><creatorcontrib>Mercuro, Giuseppe, MD</creatorcontrib><creatorcontrib>Grassi, Roberto, MD</creatorcontrib><creatorcontrib>Suri, Jasjit S., MD, PhD</creatorcontrib><creatorcontrib>Piga, Mario, MD</creatorcontrib><title>Is There an Association between Cerebral Microbleeds and Leukoaraiosis?</title><title>Journal of stroke and cerebrovascular diseases</title><addtitle>J Stroke Cerebrovasc Dis</addtitle><description>Purpose Cerebral microbleeds (CMBs) are small dot-like lesions appearing as hyposignals on gradient echo (GRE) T2* magnetic resonance (MR) sequences, whereas the leukoaraiosis (LA) indicates the presence of patchy areas of hypersignal on fluid-attenuated inversion recovery (FLAIR) MR sequences in the periventricular white matter. The purpose of this work was to evaluate the association between LA and CMBs. Material and Methods Eighty-five consecutive (men 55; median age 64 years) patients were retrospectively analyzed using a 1.5 T system; CMBs were studied using a T2*-weighted GRE sequence and classified as absent (grade 1), mild (grade 2; total number of microbleeds, 1-2), moderate (grade 3; total number of microbleeds, 3-10), and severe (grade 4; total number of microbleeds, >10). LA was assessed with FLAIR MR sequences and was graded based on the European Task Force on Age-Related White Matter Changes as follows: 1 (no lesions), 2 (focal lesions > 5 mm), 3 (early confluent lesions), and 4 (diffuse involvement of an entire brain region). Results We considered 170 cerebral hemispheres. The prevalence of CMBs was 24.7% (42 of 170), whereas the prevalence of LA was 27.1% (46 of 170). A statistically significant correlation was observed between LA and CMBs (correlation rho = .495, P value = .001). Multiple logistic regression analysis showed an association between CMBs and cerebrovascular symptoms ( P = .0023). Conclusion Results of this study suggest an association between CMBs and LA. Moreover, we found that LA is associated with the presence of cerebrovascular symptoms.</description><subject>Aged</subject><subject>Brain - pathology</subject><subject>Cardiovascular</subject><subject>Cerebral Hemorrhage - epidemiology</subject><subject>Cerebral Hemorrhage - pathology</subject><subject>Cerebral microbleeds</subject><subject>CMB</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Humans</subject><subject>imaging</subject><subject>leukoaraiosis</subject><subject>Leukoaraiosis - epidemiology</subject><subject>Leukoaraiosis - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Neurology</subject><subject>Prevalence</subject><subject>Retrospective Studies</subject><issn>1052-3057</issn><issn>1532-8511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkctu1EAQRS1ERELgF5CXCMmm-jW2N6BkBCTSRFkQ1q1-lEV7PO7QZQflb_gWvoweJrCI2LDqWlydW32qKN4wqBmw1duhHmhOcYsOE9oU7wz5QDUHJmtoahDqSXHClOBVqxh7mmdQvBKgmuPiOdEAwJhq1bPimCspQcjupLi4pPLma-aVZirPiKILZg5xKi3O3xGncv27y4zlVXAp2hHRU876nz82uGyjSSZECvT-RXHUm5Hw5cN7Wnz5-OFmfVFtrj9drs82lZOqmytuLIJsrGzACymN7xvFPbRegjGcyaYH2_ZOdL3oed_ZFpnslFWi4T0KYcVp8frAvU3x24I0610gh-NoJowLabZSXCrJVZOj54doXpwoYa9vU9iZdK8Z6L1RPeh_GdV7oxoanY1myKuHvsXu0P9F_FGYA5tDAPOv7wImTS7g5NCHhG7WPob_63v3COfGMAVnxi3eIw1xSVP2q5kmrkF_3t94f2ImAcRKrcQvaomrbQ</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Saba, Luca, MD</creator><creator>Raz, Eytan, MD</creator><creator>Bassareo, Pier P., MD</creator><creator>di Martino, Michele, MD</creator><creator>de Cecco, Carlo Nicola, MD</creator><creator>Mercuro, Giuseppe, MD</creator><creator>Grassi, Roberto, MD</creator><creator>Suri, Jasjit S., MD, PhD</creator><creator>Piga, Mario, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2870-3771</orcidid></search><sort><creationdate>20150201</creationdate><title>Is There an Association between Cerebral Microbleeds and Leukoaraiosis?</title><author>Saba, Luca, MD ; Raz, Eytan, MD ; Bassareo, Pier P., MD ; di Martino, Michele, MD ; de Cecco, Carlo Nicola, MD ; Mercuro, Giuseppe, MD ; Grassi, Roberto, MD ; Suri, Jasjit S., MD, PhD ; Piga, Mario, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-2abe047b470d344adf752d08d40aa2147f0b8fc39f3f2f9b8e1495b5372fe33b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Brain - pathology</topic><topic>Cardiovascular</topic><topic>Cerebral Hemorrhage - epidemiology</topic><topic>Cerebral Hemorrhage - pathology</topic><topic>Cerebral microbleeds</topic><topic>CMB</topic><topic>Comorbidity</topic><topic>Female</topic><topic>Humans</topic><topic>imaging</topic><topic>leukoaraiosis</topic><topic>Leukoaraiosis - epidemiology</topic><topic>Leukoaraiosis - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Neurology</topic><topic>Prevalence</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saba, Luca, MD</creatorcontrib><creatorcontrib>Raz, Eytan, MD</creatorcontrib><creatorcontrib>Bassareo, Pier P., MD</creatorcontrib><creatorcontrib>di Martino, Michele, MD</creatorcontrib><creatorcontrib>de Cecco, Carlo Nicola, MD</creatorcontrib><creatorcontrib>Mercuro, Giuseppe, MD</creatorcontrib><creatorcontrib>Grassi, Roberto, MD</creatorcontrib><creatorcontrib>Suri, Jasjit S., MD, PhD</creatorcontrib><creatorcontrib>Piga, Mario, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of stroke and cerebrovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saba, Luca, MD</au><au>Raz, Eytan, MD</au><au>Bassareo, Pier P., MD</au><au>di Martino, Michele, MD</au><au>de Cecco, Carlo Nicola, MD</au><au>Mercuro, Giuseppe, MD</au><au>Grassi, Roberto, MD</au><au>Suri, Jasjit S., MD, PhD</au><au>Piga, Mario, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is There an Association between Cerebral Microbleeds and Leukoaraiosis?</atitle><jtitle>Journal of stroke and cerebrovascular diseases</jtitle><addtitle>J Stroke Cerebrovasc Dis</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>24</volume><issue>2</issue><spage>284</spage><epage>289</epage><pages>284-289</pages><issn>1052-3057</issn><eissn>1532-8511</eissn><abstract>Purpose Cerebral microbleeds (CMBs) are small dot-like lesions appearing as hyposignals on gradient echo (GRE) T2* magnetic resonance (MR) sequences, whereas the leukoaraiosis (LA) indicates the presence of patchy areas of hypersignal on fluid-attenuated inversion recovery (FLAIR) MR sequences in the periventricular white matter. The purpose of this work was to evaluate the association between LA and CMBs. Material and Methods Eighty-five consecutive (men 55; median age 64 years) patients were retrospectively analyzed using a 1.5 T system; CMBs were studied using a T2*-weighted GRE sequence and classified as absent (grade 1), mild (grade 2; total number of microbleeds, 1-2), moderate (grade 3; total number of microbleeds, 3-10), and severe (grade 4; total number of microbleeds, >10). LA was assessed with FLAIR MR sequences and was graded based on the European Task Force on Age-Related White Matter Changes as follows: 1 (no lesions), 2 (focal lesions > 5 mm), 3 (early confluent lesions), and 4 (diffuse involvement of an entire brain region). Results We considered 170 cerebral hemispheres. The prevalence of CMBs was 24.7% (42 of 170), whereas the prevalence of LA was 27.1% (46 of 170). A statistically significant correlation was observed between LA and CMBs (correlation rho = .495, P value = .001). Multiple logistic regression analysis showed an association between CMBs and cerebrovascular symptoms ( P = .0023). Conclusion Results of this study suggest an association between CMBs and LA. Moreover, we found that LA is associated with the presence of cerebrovascular symptoms.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25440349</pmid><doi>10.1016/j.jstrokecerebrovasdis.2014.07.035</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-2870-3771</orcidid></addata></record> |
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| subjects | Aged Brain - pathology Cardiovascular Cerebral Hemorrhage - epidemiology Cerebral Hemorrhage - pathology Cerebral microbleeds CMB Comorbidity Female Humans imaging leukoaraiosis Leukoaraiosis - epidemiology Leukoaraiosis - pathology Magnetic Resonance Imaging Male Middle Aged MRI Neurology Prevalence Retrospective Studies |
| title | Is There an Association between Cerebral Microbleeds and Leukoaraiosis? |
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