Prognostic value of volumetric parameters of (18)F-FDG PET in non-small-cell lung cancer: a meta-analysis
We conducted a comprehensive systematic review of the literature on volumetric parameters from (18)F-FDG PET and a meta-analysis of the prognostic value of metabolic tumour volume (MTV) and total lesion glycolysis (TLG) in patients with lung cancer. A systematic search of MEDLINE and EMBASE was perf...
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| Veröffentlicht in: | European journal of nuclear medicine and molecular imaging 2015-02, Vol.42 (2), p.241-251 |
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| container_title | European journal of nuclear medicine and molecular imaging |
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| creator | Im, Hyung-Jun Pak, Kyoungjune Cheon, Gi Jeong Kang, Keon Wook Kim, Seong-Jang Kim, In-Joo Chung, June-Key Kim, E Edmund Lee, Dong Soo |
| description | We conducted a comprehensive systematic review of the literature on volumetric parameters from (18)F-FDG PET and a meta-analysis of the prognostic value of metabolic tumour volume (MTV) and total lesion glycolysis (TLG) in patients with lung cancer.
A systematic search of MEDLINE and EMBASE was performed using the keywords "positron emission tomography (PET)", "lung cancer", and "volume". Inclusion criteria were: (18)F-FDG PET used as an initial imaging tool; studies limited to non-small-cell lung cancer (NSCLC); volume measurement of lung cancer; patients who had not undergone surgery, chemotherapy, or radiotherapy before the PET scan; and studies that reported survival data. Event-free survival and overall survival were evaluated as outcomes. The impact of MTV and TLG on survival was measured in terms of the hazard ratio (HR) effect size. Data from each study were analysed using Review Manager 5.2.
Thirteen eligible studies including 1,581 patients were analysed. Patients with high MTV showed a worse prognosis with an HR of 2.71 (95% CI 1.82 - 4.02, p |
| doi_str_mv | 10.1007/s00259-014-2903-7 |
| format | Article |
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A systematic search of MEDLINE and EMBASE was performed using the keywords "positron emission tomography (PET)", "lung cancer", and "volume". Inclusion criteria were: (18)F-FDG PET used as an initial imaging tool; studies limited to non-small-cell lung cancer (NSCLC); volume measurement of lung cancer; patients who had not undergone surgery, chemotherapy, or radiotherapy before the PET scan; and studies that reported survival data. Event-free survival and overall survival were evaluated as outcomes. The impact of MTV and TLG on survival was measured in terms of the hazard ratio (HR) effect size. Data from each study were analysed using Review Manager 5.2.
Thirteen eligible studies including 1,581 patients were analysed. Patients with high MTV showed a worse prognosis with an HR of 2.71 (95% CI 1.82 - 4.02, p < 0.00001) for adverse events and an HR of 2.31 (95% CI 1.54 - 3.47, p < 0.00001) for death. Patients with high TLG also showed a worse prognosis with an HR of 2.35 (95% CI 1.91 - 2.89, p < 0.00001) for adverse events and an HR of 2.43 (95% CI 1.89 - 3.11, p < 0.00001) for death. The prognostic value of MTV and TLG remained significant in a subgroup analysis according to TNM stage as well as the methods for defining cut-off values and tumour delineation.
Volumetric parameters from (18)F-FDG PET are significant prognostic factors for outcome in patients with NSCLC. Patients with a high MTV or TLG are at higher risk of adverse events and death. MTV and TLG were significant prognostic factors in patients with TNM stage I/II and stage III/IV NSCLC.</description><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-014-2903-7</identifier><identifier>PMID: 25193652</identifier><language>eng</language><publisher>Germany</publisher><subject>Carcinoma, Non-Small-Cell Lung - diagnostic imaging ; Female ; Fluorodeoxyglucose F18 ; Humans ; Lung Neoplasms - diagnostic imaging ; Male ; Positron-Emission Tomography ; Predictive Value of Tests ; Radiopharmaceuticals</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2015-02, Vol.42 (2), p.241-251</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25193652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Im, Hyung-Jun</creatorcontrib><creatorcontrib>Pak, Kyoungjune</creatorcontrib><creatorcontrib>Cheon, Gi Jeong</creatorcontrib><creatorcontrib>Kang, Keon Wook</creatorcontrib><creatorcontrib>Kim, Seong-Jang</creatorcontrib><creatorcontrib>Kim, In-Joo</creatorcontrib><creatorcontrib>Chung, June-Key</creatorcontrib><creatorcontrib>Kim, E Edmund</creatorcontrib><creatorcontrib>Lee, Dong Soo</creatorcontrib><title>Prognostic value of volumetric parameters of (18)F-FDG PET in non-small-cell lung cancer: a meta-analysis</title><title>European journal of nuclear medicine and molecular imaging</title><addtitle>Eur J Nucl Med Mol Imaging</addtitle><description>We conducted a comprehensive systematic review of the literature on volumetric parameters from (18)F-FDG PET and a meta-analysis of the prognostic value of metabolic tumour volume (MTV) and total lesion glycolysis (TLG) in patients with lung cancer.
A systematic search of MEDLINE and EMBASE was performed using the keywords "positron emission tomography (PET)", "lung cancer", and "volume". Inclusion criteria were: (18)F-FDG PET used as an initial imaging tool; studies limited to non-small-cell lung cancer (NSCLC); volume measurement of lung cancer; patients who had not undergone surgery, chemotherapy, or radiotherapy before the PET scan; and studies that reported survival data. Event-free survival and overall survival were evaluated as outcomes. The impact of MTV and TLG on survival was measured in terms of the hazard ratio (HR) effect size. Data from each study were analysed using Review Manager 5.2.
Thirteen eligible studies including 1,581 patients were analysed. Patients with high MTV showed a worse prognosis with an HR of 2.71 (95% CI 1.82 - 4.02, p < 0.00001) for adverse events and an HR of 2.31 (95% CI 1.54 - 3.47, p < 0.00001) for death. Patients with high TLG also showed a worse prognosis with an HR of 2.35 (95% CI 1.91 - 2.89, p < 0.00001) for adverse events and an HR of 2.43 (95% CI 1.89 - 3.11, p < 0.00001) for death. The prognostic value of MTV and TLG remained significant in a subgroup analysis according to TNM stage as well as the methods for defining cut-off values and tumour delineation.
Volumetric parameters from (18)F-FDG PET are significant prognostic factors for outcome in patients with NSCLC. Patients with a high MTV or TLG are at higher risk of adverse events and death. MTV and TLG were significant prognostic factors in patients with TNM stage I/II and stage III/IV NSCLC.</description><subject>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Lung Neoplasms - diagnostic imaging</subject><subject>Male</subject><subject>Positron-Emission Tomography</subject><subject>Predictive Value of Tests</subject><subject>Radiopharmaceuticals</subject><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UMlOwzAQtZAQLYUP4IJ8LAeDlyw2N1TaglSJHso5mnqpghwn2Eml_j1BlNMbvWX0ZhC6Y_SRUVo-JUp5rghlGeGKClJeoCkrmCIllWqCrlP6opRJLtUVmvCcKVHkfIrqbWwPoU19rfER_GBx6_Cx9UNj-zhyHUQYRxvTrzBn8mFFVq9rvF3ucB1waANJDXhPtPUe-yEcsIagbXzGgMcgEAjgT6lON-jSgU_29owz9Lla7hZvZPOxfl-8bEjHeNETqbXOc6uzYl-KDAzXe02FVNpZ0E5oqRXLnHQgC2sVL4w2FkAo55gxhbFihuZ_e7vYfg829VVTp992EGw7pIqNd2c5o7kcrfdn67BvrKm6WDcQT9X_e8QPNgJmuQ</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Im, Hyung-Jun</creator><creator>Pak, Kyoungjune</creator><creator>Cheon, Gi Jeong</creator><creator>Kang, Keon Wook</creator><creator>Kim, Seong-Jang</creator><creator>Kim, In-Joo</creator><creator>Chung, June-Key</creator><creator>Kim, E Edmund</creator><creator>Lee, Dong Soo</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>Prognostic value of volumetric parameters of (18)F-FDG PET in non-small-cell lung cancer: a meta-analysis</title><author>Im, Hyung-Jun ; Pak, Kyoungjune ; Cheon, Gi Jeong ; Kang, Keon Wook ; Kim, Seong-Jang ; Kim, In-Joo ; Chung, June-Key ; Kim, E Edmund ; Lee, Dong Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-8ccc55ec46b734ad2cbc0389cfeacf3c8c914f8fa86ee926dcdeaa39ff1dd6de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Carcinoma, Non-Small-Cell Lung - diagnostic imaging</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Lung Neoplasms - diagnostic imaging</topic><topic>Male</topic><topic>Positron-Emission Tomography</topic><topic>Predictive Value of Tests</topic><topic>Radiopharmaceuticals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Im, Hyung-Jun</creatorcontrib><creatorcontrib>Pak, Kyoungjune</creatorcontrib><creatorcontrib>Cheon, Gi Jeong</creatorcontrib><creatorcontrib>Kang, Keon Wook</creatorcontrib><creatorcontrib>Kim, Seong-Jang</creatorcontrib><creatorcontrib>Kim, In-Joo</creatorcontrib><creatorcontrib>Chung, June-Key</creatorcontrib><creatorcontrib>Kim, E Edmund</creatorcontrib><creatorcontrib>Lee, Dong Soo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Im, Hyung-Jun</au><au>Pak, Kyoungjune</au><au>Cheon, Gi Jeong</au><au>Kang, Keon Wook</au><au>Kim, Seong-Jang</au><au>Kim, In-Joo</au><au>Chung, June-Key</au><au>Kim, E Edmund</au><au>Lee, Dong Soo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of volumetric parameters of (18)F-FDG PET in non-small-cell lung cancer: a meta-analysis</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><addtitle>Eur J Nucl Med Mol Imaging</addtitle><date>2015-02</date><risdate>2015</risdate><volume>42</volume><issue>2</issue><spage>241</spage><epage>251</epage><pages>241-251</pages><eissn>1619-7089</eissn><abstract>We conducted a comprehensive systematic review of the literature on volumetric parameters from (18)F-FDG PET and a meta-analysis of the prognostic value of metabolic tumour volume (MTV) and total lesion glycolysis (TLG) in patients with lung cancer.
A systematic search of MEDLINE and EMBASE was performed using the keywords "positron emission tomography (PET)", "lung cancer", and "volume". Inclusion criteria were: (18)F-FDG PET used as an initial imaging tool; studies limited to non-small-cell lung cancer (NSCLC); volume measurement of lung cancer; patients who had not undergone surgery, chemotherapy, or radiotherapy before the PET scan; and studies that reported survival data. Event-free survival and overall survival were evaluated as outcomes. The impact of MTV and TLG on survival was measured in terms of the hazard ratio (HR) effect size. Data from each study were analysed using Review Manager 5.2.
Thirteen eligible studies including 1,581 patients were analysed. Patients with high MTV showed a worse prognosis with an HR of 2.71 (95% CI 1.82 - 4.02, p < 0.00001) for adverse events and an HR of 2.31 (95% CI 1.54 - 3.47, p < 0.00001) for death. Patients with high TLG also showed a worse prognosis with an HR of 2.35 (95% CI 1.91 - 2.89, p < 0.00001) for adverse events and an HR of 2.43 (95% CI 1.89 - 3.11, p < 0.00001) for death. The prognostic value of MTV and TLG remained significant in a subgroup analysis according to TNM stage as well as the methods for defining cut-off values and tumour delineation.
Volumetric parameters from (18)F-FDG PET are significant prognostic factors for outcome in patients with NSCLC. Patients with a high MTV or TLG are at higher risk of adverse events and death. MTV and TLG were significant prognostic factors in patients with TNM stage I/II and stage III/IV NSCLC.</abstract><cop>Germany</cop><pmid>25193652</pmid><doi>10.1007/s00259-014-2903-7</doi><tpages>11</tpages></addata></record> |
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| subjects | Carcinoma, Non-Small-Cell Lung - diagnostic imaging Female Fluorodeoxyglucose F18 Humans Lung Neoplasms - diagnostic imaging Male Positron-Emission Tomography Predictive Value of Tests Radiopharmaceuticals |
| title | Prognostic value of volumetric parameters of (18)F-FDG PET in non-small-cell lung cancer: a meta-analysis |
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