Targeting glycosaminoglycans in the lung by an engineered CXCL8 as a novel therapeutic approach to lung inflammation

It is broadly recognized that chemokine-activated neutrophils play a crucial role in the inflammation and disruption of lung tissue observed in several acute and chronic lung diseases. Since glycosaminoglycan side chains of proteoglycans act as chemokine co-receptors in inflammation, we have used a...

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Veröffentlicht in:	European journal of pharmacology 2015-02, Vol.748, p.83-92
Hauptverfasser:	Adage, Tiziana, Konya, Viktoria, Weber, Corinna, Strutzmann, Elisabeth, Fuchs, Thomas, Zankl, Christina, Gerlza, Tanja, Jeremic, Dalibor, Heinemann, Akos, Kungl, Andreas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Chemokine Endothelial Cells - drug effects Endothelial Cells - metabolism Female Gene Expression Regulation - drug effects Glycosaminoglycan Glycosaminoglycans - metabolism Heparan sulfate Humans Inflammation Interleukin-8 - genetics Interleukin-8 - metabolism Interleukin-8 - pharmacology Interleukin-8 - therapeutic use Lipopolysaccharides - pharmacology Lung - drug effects Lung - immunology Lung - metabolism Male Mice Microvessels - cytology Molecular Targeted Therapy - methods Neutrophil Infiltration - drug effects Neutrophils Pneumonia - drug therapy Pneumonia - genetics Pneumonia - immunology Pneumonia - metabolism Protein Engineering Smoke - adverse effects Syndecan-4 - genetics
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