HER2‐positive gastric cancer with concomitant MET and/or EGFR overexpression: A distinct subset of patients for dual inhibition therapy

Growth factor receptors, often carrying tyrosine kinase activities in their cytoplasmic domains, are overexpressed in many cancers. Coactivation of receptor tyrosine kinases (RTKs) plays a critical role in tumor response to targeted therapeutics. We examined concomitant overexpression of EGFR and ME...

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Veröffentlicht in:	International journal of cancer 2015-04, Vol.136 (7), p.1629-1635
Hauptverfasser:	Ha, Sang Yun, Lee, Jeeyun, Jang, Jiryeon, Hong, Jung Yong, Do, In‐Gu, Park, Se Hoon, Park, Joon Oh, Choi, Min‐Gew, Sohn, Tae Sung, Bae, Jae Moon, Kim, Sung, Kim, Minji, Kim, Seonwoo, Park, Cheol Keun, Kang, Won Ki, Kim, Kyoung‐Mee
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antineoplastic Agents - therapeutic use Cancer Cancer therapies coactivation EGFR Female Gastric cancer gastric carcinoma Gene Amplification Gene Expression HER2 Histology Humans Immunohistochemistry In Situ Hybridization, Fluorescence Male Medical research MET Middle Aged Neoplasm Grading Neoplasm Staging Patients Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins c-met - antagonists & inhibitors Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - antagonists & inhibitors Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Stomach Neoplasms - diagnosis Stomach Neoplasms - genetics Stomach Neoplasms - mortality Stomach Neoplasms - therapy therapy Tumor Burden
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