Secondary Malignant Neoplasms after Osteosarcoma: Early Onset and Cumulative Alkylating Agent Dose Dependency

Purpose To analyze the impacts of chemotherapeutic agent exposures on the development of secondary malignant neoplasms (SMP) after osteosarcoma. Methods Of 132 patients who had been treated for high-grade extremity osteosarcoma from September 1992 to September 2008, 90 survivors were retrospectively...

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Veröffentlicht in:	Annals of surgical oncology 2015-03, Vol.22 (3), p.859-865
Hauptverfasser:	Kim, Seung Hyun, Shin, Kyoo-Ho, Seok, Sang Ok, Cho, Yong Jin, Noh, Jae Kyoung, Suh, Jin-Suck, Yang, Woo-Ick
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alkylating Agents - administration & dosage Antineoplastic Combined Chemotherapy Protocols - administration & dosage Bone and Soft Tissue Sarcomas Bone Neoplasms - drug therapy Bone Neoplasms - mortality Bone Neoplasms - pathology Child Child, Preschool Cisplatin - administration & dosage Dose-Response Relationship, Drug Doxorubicin - administration & dosage Female Follow-Up Studies Humans Ifosfamide - administration & dosage Incidence Male Medicine Medicine & Public Health Middle Aged Neoplasm Staging Neoplasms, Second Primary - epidemiology Oncology Osteosarcoma - drug therapy Osteosarcoma - mortality Osteosarcoma - pathology Prognosis Retrospective Studies Risk Factors Surgery Surgical Oncology Survival Rate Survivors Young Adult
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