p53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB

In recent years, miR-1246 has been identified as a transcriptional target of p53 in Down syndrome and may provide a new p53-miR-1246-DYRK1A-NFAT pathway in cancer. The present study aimed to explore the role of miR-1246 in the tumorigenesis of human hepatocellular carcinoma (HCC). We found that wild...

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Veröffentlicht in:	Oncology reports 2015-03, Vol.33 (3), p.1335-1341
Hauptverfasser:	ZHANG, QUAN, CAO, LI-YE, CHENG, SHU-JIE, ZHANG, AI-MIN, JIN, XIAO-SHI, LI, YONG
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - genetics Breast cancer Carcinoma, Hepatocellular - genetics Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Cell Transformation, Neoplastic - genetics Development and progression Gene expression Gene Expression Regulation, Neoplastic HCC Health aspects Hep G2 Cells Hepatoma Humans Kinases Laboratories Liver cancer Liver Neoplasms - genetics MicroRNA MicroRNAs - biosynthesis MicroRNAs - genetics MicroRNAs - metabolism miR-1246 NFI Transcription Factors - biosynthesis NFI Transcription Factors - genetics NFI Transcription Factors - metabolism NFIB Oncogenes Prevention RNA Interference RNA, Small Interfering Statistical analysis Transcription factors Tumor proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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