Correlation between Vitamin D receptor gene FOKI and BSMI polymorphisms and the susceptibility to pulmonary tuberculosis in an Indonesian Batak-ethnic population
To explore the role of FokI and BsmI polymorphisms the VDR gene in the susceptibility to pulmonary tuberculosis (PTB) in an Indonesian Batak ethnic population. Matched case-control study was conducted on 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D Receptor (VDR)...
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| Veröffentlicht in: | Acta medica Indonesiana 2014-10, Vol.46 (4), p.275-282 |
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| creator | Sinaga, Bintang Y M Amin, Muhammad Siregar, Yahwardiah Sarumpaet, Sori M |
| description | To explore the role of FokI and BsmI polymorphisms the VDR gene in the susceptibility to pulmonary tuberculosis (PTB) in an Indonesian Batak ethnic population.
Matched case-control study was conducted on 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D Receptor (VDR) gene were analysed using PCR-RFLP.
The frequencies of FokI genotypes were FF 35.5%, Ff 55.3%, ff 9.2% for PTB patients and FF 39.5%, Ff 44.7.% and ff 15.8% for normal control. The BsmI genotypes frequencies were BB 0%, Bb 68.4%, bb 31.6% for TB patients and BB 2.6%, Bb 23.7% and bb 73.7% for control. There was no significant association between FokI genotype and PTB (OR 1.39, 95% CI: 0.69-2.77 for Ff genotype and OR 0.64, 95% CI: 0.22-1.86 for ff genotype). There was a significant association between BsmI genotype and PTB; the bb genotype was associated with a decreased risk to PTB (OR 0.22, 95% CI: 0.11-0.45).
In Indonesian Batak ethnic population, there was no association between FokI polymorphism of VDR gene with host susceptibility to PTB. There was a significant association between BsmI polymorphism of VDR gene; bb genotype was associated with a decreased risk to PTB. |
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Matched case-control study was conducted on 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D Receptor (VDR) gene were analysed using PCR-RFLP.
The frequencies of FokI genotypes were FF 35.5%, Ff 55.3%, ff 9.2% for PTB patients and FF 39.5%, Ff 44.7.% and ff 15.8% for normal control. The BsmI genotypes frequencies were BB 0%, Bb 68.4%, bb 31.6% for TB patients and BB 2.6%, Bb 23.7% and bb 73.7% for control. There was no significant association between FokI genotype and PTB (OR 1.39, 95% CI: 0.69-2.77 for Ff genotype and OR 0.64, 95% CI: 0.22-1.86 for ff genotype). There was a significant association between BsmI genotype and PTB; the bb genotype was associated with a decreased risk to PTB (OR 0.22, 95% CI: 0.11-0.45).
In Indonesian Batak ethnic population, there was no association between FokI polymorphism of VDR gene with host susceptibility to PTB. There was a significant association between BsmI polymorphism of VDR gene; bb genotype was associated with a decreased risk to PTB.</description><identifier>ISSN: 0125-9326</identifier><identifier>PMID: 25633543</identifier><language>eng</language><publisher>Indonesia</publisher><subject>Adolescent ; Adult ; Case-Control Studies ; Ethnic Groups - genetics ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Indonesia - ethnology ; Male ; Middle Aged ; Polymorphism, Genetic ; Receptors, Calcitriol - genetics ; Tuberculosis, Pulmonary - ethnology ; Tuberculosis, Pulmonary - genetics ; Young Adult</subject><ispartof>Acta medica Indonesiana, 2014-10, Vol.46 (4), p.275-282</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25633543$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sinaga, Bintang Y M</creatorcontrib><creatorcontrib>Amin, Muhammad</creatorcontrib><creatorcontrib>Siregar, Yahwardiah</creatorcontrib><creatorcontrib>Sarumpaet, Sori M</creatorcontrib><title>Correlation between Vitamin D receptor gene FOKI and BSMI polymorphisms and the susceptibility to pulmonary tuberculosis in an Indonesian Batak-ethnic population</title><title>Acta medica Indonesiana</title><addtitle>Acta Med Indones</addtitle><description>To explore the role of FokI and BsmI polymorphisms the VDR gene in the susceptibility to pulmonary tuberculosis (PTB) in an Indonesian Batak ethnic population.
Matched case-control study was conducted on 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D Receptor (VDR) gene were analysed using PCR-RFLP.
The frequencies of FokI genotypes were FF 35.5%, Ff 55.3%, ff 9.2% for PTB patients and FF 39.5%, Ff 44.7.% and ff 15.8% for normal control. The BsmI genotypes frequencies were BB 0%, Bb 68.4%, bb 31.6% for TB patients and BB 2.6%, Bb 23.7% and bb 73.7% for control. There was no significant association between FokI genotype and PTB (OR 1.39, 95% CI: 0.69-2.77 for Ff genotype and OR 0.64, 95% CI: 0.22-1.86 for ff genotype). There was a significant association between BsmI genotype and PTB; the bb genotype was associated with a decreased risk to PTB (OR 0.22, 95% CI: 0.11-0.45).
In Indonesian Batak ethnic population, there was no association between FokI polymorphism of VDR gene with host susceptibility to PTB. There was a significant association between BsmI polymorphism of VDR gene; bb genotype was associated with a decreased risk to PTB.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Ethnic Groups - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Indonesia - ethnology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Tuberculosis, Pulmonary - ethnology</subject><subject>Tuberculosis, Pulmonary - genetics</subject><subject>Young Adult</subject><issn>0125-9326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UMtOwzAQzAFEq9JfQD5yiWTHcR5HWihEFHHgcY3WyYYaEjvYjlA_hz_FlLKXfWhnNDMn0ZyyRMQlT7JZtHTunVLKKOdFnp1Fs0RknIuUz6PvtbEWe_DKaCLRfyFq8qo8DEqTa2KxwdEbS95QI9k83lcEdEtWTw8VGU2_H4wdd8oN7nD2OyRucr8QJVWv_J54Q8apH4wGG5ZJom2m3jjlSOAHTSrdGo1OhXEFHj5i9DutmkAeYAdV59FpB73D5bEvopfNzfP6Lt4-3lbrq208Joz5WLbAgHXQQiIFlklBG1YiCEgLmpcoM1mItIFSJIJnOVJagqCQdSXveCHzgi-iyz_e0ZrPCZ2vBxWs9D1oNJOrWSaSNFRIbhFdHF8nOWBbj1YNwV_9Hyv_AVQndxk</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Sinaga, Bintang Y M</creator><creator>Amin, Muhammad</creator><creator>Siregar, Yahwardiah</creator><creator>Sarumpaet, Sori M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20141001</creationdate><title>Correlation between Vitamin D receptor gene FOKI and BSMI polymorphisms and the susceptibility to pulmonary tuberculosis in an Indonesian Batak-ethnic population</title><author>Sinaga, Bintang Y M ; Amin, Muhammad ; Siregar, Yahwardiah ; Sarumpaet, Sori M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-bda1a1fada2b5e9280c19ea5a48079eb6b854ca9525367e009a50a6f93f38b783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Ethnic Groups - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Indonesia - ethnology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Receptors, Calcitriol - genetics</topic><topic>Tuberculosis, Pulmonary - ethnology</topic><topic>Tuberculosis, Pulmonary - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sinaga, Bintang Y M</creatorcontrib><creatorcontrib>Amin, Muhammad</creatorcontrib><creatorcontrib>Siregar, Yahwardiah</creatorcontrib><creatorcontrib>Sarumpaet, Sori M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta medica Indonesiana</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sinaga, Bintang Y M</au><au>Amin, Muhammad</au><au>Siregar, Yahwardiah</au><au>Sarumpaet, Sori M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between Vitamin D receptor gene FOKI and BSMI polymorphisms and the susceptibility to pulmonary tuberculosis in an Indonesian Batak-ethnic population</atitle><jtitle>Acta medica Indonesiana</jtitle><addtitle>Acta Med Indones</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>46</volume><issue>4</issue><spage>275</spage><epage>282</epage><pages>275-282</pages><issn>0125-9326</issn><abstract>To explore the role of FokI and BsmI polymorphisms the VDR gene in the susceptibility to pulmonary tuberculosis (PTB) in an Indonesian Batak ethnic population.
Matched case-control study was conducted on 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D Receptor (VDR) gene were analysed using PCR-RFLP.
The frequencies of FokI genotypes were FF 35.5%, Ff 55.3%, ff 9.2% for PTB patients and FF 39.5%, Ff 44.7.% and ff 15.8% for normal control. The BsmI genotypes frequencies were BB 0%, Bb 68.4%, bb 31.6% for TB patients and BB 2.6%, Bb 23.7% and bb 73.7% for control. There was no significant association between FokI genotype and PTB (OR 1.39, 95% CI: 0.69-2.77 for Ff genotype and OR 0.64, 95% CI: 0.22-1.86 for ff genotype). There was a significant association between BsmI genotype and PTB; the bb genotype was associated with a decreased risk to PTB (OR 0.22, 95% CI: 0.11-0.45).
In Indonesian Batak ethnic population, there was no association between FokI polymorphism of VDR gene with host susceptibility to PTB. There was a significant association between BsmI polymorphism of VDR gene; bb genotype was associated with a decreased risk to PTB.</abstract><cop>Indonesia</cop><pmid>25633543</pmid><tpages>8</tpages></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Adult Case-Control Studies Ethnic Groups - genetics Female Genetic Predisposition to Disease Genotype Humans Indonesia - ethnology Male Middle Aged Polymorphism, Genetic Receptors, Calcitriol - genetics Tuberculosis, Pulmonary - ethnology Tuberculosis, Pulmonary - genetics Young Adult |
| title | Correlation between Vitamin D receptor gene FOKI and BSMI polymorphisms and the susceptibility to pulmonary tuberculosis in an Indonesian Batak-ethnic population |
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