The rs13064411 polymorphism in the WDR52 gene, associated with PCSK9 levels, modifies statin-induced changes in serum total and LDL cholesterol levels

OBJECTIVERecently, the minor allele of the rs13064411A>G polymorphism in the WD repeat domain 52 (WDR52) gene was associated with increased statin-induced proprotein convertase subtilisin/kexin type 9 (PCSK9) levels and with LDL cholesterol response to statins. PCSK9 promotes LDL receptor degrada...

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Veröffentlicht in:	Pharmacogenetics and genomics 2015-03, Vol.25 (3), p.134-142
Hauptverfasser:	de Keyser, Catherine E, Becker, Matthijs L, Hofman, Albert, Lous, Jan J, Uitterlinden, André G, Visser, Loes E, Stricker, Bruno H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anticholesteremic Agents - administration & dosage Anticholesteremic Agents - pharmacology Cholesterol, LDL - blood Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Male Middle Aged Nuclear Proteins - genetics Peptide Hydrolases Polymorphism, Genetic Proprotein Convertase 9 Proprotein Convertases - metabolism Prospective Studies Proteins - genetics Receptors, LDL - metabolism Serine Endopeptidases - metabolism Sex Characteristics
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