A comparison of postoperative effects of bariatric surgery on medical markers of morbidity
Abstract Background Bariatric surgery reduces the prevalence of diabetes and improves lipid profiles. Low-density lipoprotein particle (LDL-P) is a more accurate predictor of cardiovascular events than high-density lipoprotein (HDL) and LDL cholesterol. The effects of bariatric procedures on LDL-P h...
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| Veröffentlicht in: | The American journal of surgery 2014-12, Vol.208 (6), p.897-902 |
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| creator | Bonner, Gwen L., M.D Nagy, Andrew J., B.S Jupiter, Daniel C., Ph.D Rodriguez, Joaquin A., M.D Symmonds, Richard E., M.D Carpenter, Robert O., M.D., M.P.H |
| description | Abstract Background Bariatric surgery reduces the prevalence of diabetes and improves lipid profiles. Low-density lipoprotein particle (LDL-P) is a more accurate predictor of cardiovascular events than high-density lipoprotein (HDL) and LDL cholesterol. The effects of bariatric procedures on LDL-P have not been previously reported. Methods Two hundred thirty patients undergoing bariatric surgery, including gastric bypass, sleeve gastrectomy, and laparoscopic adjustable gastric band placement at a single institution were included. HDL, LDL, hemoglobin A1c, and LDL-P were measured preoperatively and at 3, 6, and 12 months postoperatively. Weight was recorded at baseline and after 1 year. Results There was a decrease in serum LDL-P levels, averaging 472.58 ( P < .0001) over 1 year. HDL levels increased. Hemoglobin A1c and LDL levels declined. On average, patients lost 58% of excess weight. Conclusion LDL-P significantly decreased after bariatric surgery in relation to weight loss. It may be inferred that bariatric surgery decreases the risk of cardiovascular events. |
| doi_str_mv | 10.1016/j.amjsurg.2014.09.005 |
| format | Article |
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Low-density lipoprotein particle (LDL-P) is a more accurate predictor of cardiovascular events than high-density lipoprotein (HDL) and LDL cholesterol. The effects of bariatric procedures on LDL-P have not been previously reported. Methods Two hundred thirty patients undergoing bariatric surgery, including gastric bypass, sleeve gastrectomy, and laparoscopic adjustable gastric band placement at a single institution were included. HDL, LDL, hemoglobin A1c, and LDL-P were measured preoperatively and at 3, 6, and 12 months postoperatively. Weight was recorded at baseline and after 1 year. Results There was a decrease in serum LDL-P levels, averaging 472.58 ( P < .0001) over 1 year. HDL levels increased. Hemoglobin A1c and LDL levels declined. On average, patients lost 58% of excess weight. Conclusion LDL-P significantly decreased after bariatric surgery in relation to weight loss. It may be inferred that bariatric surgery decreases the risk of cardiovascular events.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2014.09.005</identifier><identifier>PMID: 25440477</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Bariatric Surgery ; Biomarkers - blood ; Body mass index ; Cardiovascular disease ; Cardiovascular risk ; Cholesterol ; Coronary Artery Disease - blood ; Coronary Artery Disease - prevention & control ; Female ; Glycated Hemoglobin A - metabolism ; Humans ; Hyperlipidemias - blood ; Hyperlipidemias - prevention & control ; Hypertension - blood ; Hypertension - prevention & control ; Laboratories ; Laparoscopy ; LDL particle ; Lipids - blood ; Male ; Morbidity ; Obesity ; Obesity, Morbid - blood ; Obesity, Morbid - surgery ; Retrospective Studies ; Surgery ; Weight Loss</subject><ispartof>The American journal of surgery, 2014-12, Vol.208 (6), p.897-902</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Dec 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-756b57b93813207a9908aa98208b2356f353f07e4e9c99bf2559c091a3ac65bf3</citedby><cites>FETCH-LOGICAL-c448t-756b57b93813207a9908aa98208b2356f353f07e4e9c99bf2559c091a3ac65bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1628966008?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25440477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonner, Gwen L., M.D</creatorcontrib><creatorcontrib>Nagy, Andrew J., B.S</creatorcontrib><creatorcontrib>Jupiter, Daniel C., Ph.D</creatorcontrib><creatorcontrib>Rodriguez, Joaquin A., M.D</creatorcontrib><creatorcontrib>Symmonds, Richard E., M.D</creatorcontrib><creatorcontrib>Carpenter, Robert O., M.D., M.P.H</creatorcontrib><title>A comparison of postoperative effects of bariatric surgery on medical markers of morbidity</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background Bariatric surgery reduces the prevalence of diabetes and improves lipid profiles. Low-density lipoprotein particle (LDL-P) is a more accurate predictor of cardiovascular events than high-density lipoprotein (HDL) and LDL cholesterol. The effects of bariatric procedures on LDL-P have not been previously reported. Methods Two hundred thirty patients undergoing bariatric surgery, including gastric bypass, sleeve gastrectomy, and laparoscopic adjustable gastric band placement at a single institution were included. HDL, LDL, hemoglobin A1c, and LDL-P were measured preoperatively and at 3, 6, and 12 months postoperatively. Weight was recorded at baseline and after 1 year. Results There was a decrease in serum LDL-P levels, averaging 472.58 ( P < .0001) over 1 year. HDL levels increased. Hemoglobin A1c and LDL levels declined. On average, patients lost 58% of excess weight. Conclusion LDL-P significantly decreased after bariatric surgery in relation to weight loss. It may be inferred that bariatric surgery decreases the risk of cardiovascular events.</description><subject>Bariatric Surgery</subject><subject>Biomarkers - blood</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular risk</subject><subject>Cholesterol</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - prevention & control</subject><subject>Female</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Humans</subject><subject>Hyperlipidemias - blood</subject><subject>Hyperlipidemias - prevention & control</subject><subject>Hypertension - blood</subject><subject>Hypertension - prevention & control</subject><subject>Laboratories</subject><subject>Laparoscopy</subject><subject>LDL particle</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Morbidity</subject><subject>Obesity</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - surgery</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Weight Loss</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkstu1DAUQC0EokPhE0CR2LBJuH4l9gZUVTwqVWLRsmFjOZ4b5DSJg51Umr_HYQaQuunKsnzu6_gS8ppCRYHW7_vKjn1a48-KARUV6ApAPiE7qhpdUqX4U7IDAFbqmsIZeZFSn6-UCv6cnDEpBIim2ZEfF4UL42yjT2EqQlfMIS1hxmgXf48Fdh26JW0PbWbsEr0rtqoYD0UOGHHvnR2K0cY7jH-4McTW7_1yeEmedXZI-Op0npPvnz_dXn4tr799ubq8uC6dEGopG1m3smk1V5QzaKzWoKzVioFqGZd1xyXvoEGB2mnddkxK7UBTy62rZdvxc_LumHeO4deKaTGjTw6HwU4Y1mRoLZkQXDCZ0bcP0D6sccrdZYopXdcAKlPySLkYUorYmTn6POHBUDCbfNObk3yzyTegTZaf496csq9tFvMv6q_tDHw8Aph13HuMJjmPk8sSY9Zs9sE_WuLDgwxu8NP2BXd4wPR_GpOYAXOzbcC2AFQAZAcN_w0LqaxJ</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Bonner, Gwen L., M.D</creator><creator>Nagy, Andrew J., B.S</creator><creator>Jupiter, Daniel C., Ph.D</creator><creator>Rodriguez, Joaquin A., M.D</creator><creator>Symmonds, Richard E., M.D</creator><creator>Carpenter, Robert O., M.D., M.P.H</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20141201</creationdate><title>A comparison of postoperative effects of bariatric surgery on medical markers of morbidity</title><author>Bonner, Gwen L., M.D ; Nagy, Andrew J., B.S ; Jupiter, Daniel C., Ph.D ; Rodriguez, Joaquin A., M.D ; Symmonds, Richard E., M.D ; Carpenter, Robert O., M.D., M.P.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-756b57b93813207a9908aa98208b2356f353f07e4e9c99bf2559c091a3ac65bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Bariatric Surgery</topic><topic>Biomarkers - blood</topic><topic>Body mass index</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular risk</topic><topic>Cholesterol</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - prevention & control</topic><topic>Female</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Humans</topic><topic>Hyperlipidemias - blood</topic><topic>Hyperlipidemias - prevention & control</topic><topic>Hypertension - blood</topic><topic>Hypertension - prevention & control</topic><topic>Laboratories</topic><topic>Laparoscopy</topic><topic>LDL particle</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Morbidity</topic><topic>Obesity</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - surgery</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bonner, Gwen L., M.D</creatorcontrib><creatorcontrib>Nagy, Andrew J., B.S</creatorcontrib><creatorcontrib>Jupiter, Daniel C., Ph.D</creatorcontrib><creatorcontrib>Rodriguez, Joaquin A., M.D</creatorcontrib><creatorcontrib>Symmonds, Richard E., M.D</creatorcontrib><creatorcontrib>Carpenter, Robert O., M.D., M.P.H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bonner, Gwen L., M.D</au><au>Nagy, Andrew J., B.S</au><au>Jupiter, Daniel C., Ph.D</au><au>Rodriguez, Joaquin A., M.D</au><au>Symmonds, Richard E., M.D</au><au>Carpenter, Robert O., M.D., M.P.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of postoperative effects of bariatric surgery on medical markers of morbidity</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>208</volume><issue>6</issue><spage>897</spage><epage>902</epage><pages>897-902</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>Abstract Background Bariatric surgery reduces the prevalence of diabetes and improves lipid profiles. Low-density lipoprotein particle (LDL-P) is a more accurate predictor of cardiovascular events than high-density lipoprotein (HDL) and LDL cholesterol. The effects of bariatric procedures on LDL-P have not been previously reported. Methods Two hundred thirty patients undergoing bariatric surgery, including gastric bypass, sleeve gastrectomy, and laparoscopic adjustable gastric band placement at a single institution were included. HDL, LDL, hemoglobin A1c, and LDL-P were measured preoperatively and at 3, 6, and 12 months postoperatively. Weight was recorded at baseline and after 1 year. Results There was a decrease in serum LDL-P levels, averaging 472.58 ( P < .0001) over 1 year. HDL levels increased. Hemoglobin A1c and LDL levels declined. On average, patients lost 58% of excess weight. Conclusion LDL-P significantly decreased after bariatric surgery in relation to weight loss. It may be inferred that bariatric surgery decreases the risk of cardiovascular events.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25440477</pmid><doi>10.1016/j.amjsurg.2014.09.005</doi><tpages>6</tpages></addata></record> |
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| subjects | Bariatric Surgery Biomarkers - blood Body mass index Cardiovascular disease Cardiovascular risk Cholesterol Coronary Artery Disease - blood Coronary Artery Disease - prevention & control Female Glycated Hemoglobin A - metabolism Humans Hyperlipidemias - blood Hyperlipidemias - prevention & control Hypertension - blood Hypertension - prevention & control Laboratories Laparoscopy LDL particle Lipids - blood Male Morbidity Obesity Obesity, Morbid - blood Obesity, Morbid - surgery Retrospective Studies Surgery Weight Loss |
| title | A comparison of postoperative effects of bariatric surgery on medical markers of morbidity |
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