Preferential recognition of peroxynitrite-modified human serum albumin by circulating autoantibodies in cancer

Peroxynitrite is a potent oxidizing and nitrating agent and has in vivo existence. Several studies have shown the damaging role of this molecule in biological system. Human serum albumin (HSA), being most abundant plasma protein, is easily targeted by different oxidizing and nitrating agents. Free r...

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Veröffentlicht in:	International journal of biological macromolecules 2015-01, Vol.72, p.875-882
Hauptverfasser:	Ahmad, Parvez, ul Islam, Badar, Allarakha, Shaziya, Rabbani, Gulam, Dixit, Kiran, Moinuddin, Khan, Rizwan Hasan, Siddiqui, Shahid Ali, Ali, Asif
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Autoantibodies - immunology Calorimetry, Differential Scanning Case-Control Studies Female Free Radicals - toxicity Hemolysis - drug effects Humans Immunoglobulin G Male Middle Aged Neoplasms - immunology Peroxynitrous Acid - chemistry Protein Binding - immunology Serum Albumin - chemistry Serum Albumin - immunology Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Thermodynamics Young Adult
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