Acquired cystic disease‐associated renal cell carcinoma with a focal sarcomatoid component: Report of a case showing more pronounced polysomy of chromosomes 3 and 16 in the sarcomatoid component
Acquired cystic disease (ACD)‐associated renal cell carcinoma (RCC) has recently been established. Herein we report the sixth case of ACD‐associated RCC with a sarcomatoid change. The patient was a 77‐year‐old man who regularly underwent hemodialysis for 14 years due to chronic renal failure resulti...
Gespeichert in:
Veröffentlicht in: | Pathology international 2015-02, Vol.65 (2), p.89-94 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 94 |
---|---|
container_issue | 2 |
container_start_page | 89 |
container_title | Pathology international |
container_volume | 65 |
creator | Tajima, Shogo Waki, Michihiko Doi, Wataru Hayashi, Kazumasa Takenaka, Syunsuke Fukaya, Yoshie Kimura, Ryosuke |
description | Acquired cystic disease (ACD)‐associated renal cell carcinoma (RCC) has recently been established. Herein we report the sixth case of ACD‐associated RCC with a sarcomatoid change. The patient was a 77‐year‐old man who regularly underwent hemodialysis for 14 years due to chronic renal failure resulting from IgA nephropathy. On computed tomography, a large right RCC was observed with contrast enhancement in the arterial phase. A nodular protrusion into the perirenal fat was detected. Right nephrectomy was performed under laparoscopy. Surgically resected specimens revealed a tan‐to‐yellow tumor (95 × 75 × 55 mm) with a whitish nodule (20 × 15 × 15 mm) invading into the perirenal fat. Histopathologically, the large carcinoma component of the tumor displayed a cribriform or microcystic growth pattern with deposition of oxalate crystals. The whitish nodule corresponded to the sarcomatoid component, and the spindled and pleomorphic tumor cells showed diffuse positivity of p53 on immunohistochemistry. Fluorescence in situ hybridization revealed trisomy of chromosomes 3 and 16 in the carcinoma component, as was expected from the literature. In addition, increased polysomy of these chromosomes was also observed in the sarcomatoid component. This finding may be related to the development of the sarcomatoid component along with the TP53 mutation. |
doi_str_mv | 10.1111/pin.12232 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1652437820</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1652437820</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3492-685120e23885a85c181c710705ec086b517d72778d8d816b8f1f7f3745691d2e3</originalsourceid><addsrcrecordid>eNp1kctu1TAQhiMEoqWw4AWQl7BI67HjS9lVFZRKFSAE68jHmXCMEju1Ex1lxyPwUDxJn4Q5nMIKPJIvM5_-GfmvqufAT4HW2RTiKQghxYPqGJqG12CFeUh3KXitGi2PqielfOMcjNT8cXUkVCMaBfq4-nnhb5eQsWN-LXPwrAsFXcG77z9cKckHN1MtY3QD8zjQ5rIPMY2O7cK8ZY71yVOtUJqScwqklMYpRYzza_YJp5RnlnoCPcmysk27EL-yMWVkU04xLdFThykNa0njukf9Nqcx0QsLk8zFjoFmIbJ5i__u87R61Luh4LP786T68vbN58t39c2Hq-vLi5vay-Zc1NoqEByFtFY5qzxY8Aa44Qo9t3qjwHRGGGM7CtAb20Nvemkapc-hEyhPqpcHXRr8dsEyt2Mo-19xEdNSWtBKNNJYwQl9dUB9TqVk7Nsph9HltQXe7k1rybT2t2nEvriXXTYjdn_JPy4RcHYAdmHA9f9K7cfr9wfJX4nwpKE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652437820</pqid></control><display><type>article</type><title>Acquired cystic disease‐associated renal cell carcinoma with a focal sarcomatoid component: Report of a case showing more pronounced polysomy of chromosomes 3 and 16 in the sarcomatoid component</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Tajima, Shogo ; Waki, Michihiko ; Doi, Wataru ; Hayashi, Kazumasa ; Takenaka, Syunsuke ; Fukaya, Yoshie ; Kimura, Ryosuke</creator><creatorcontrib>Tajima, Shogo ; Waki, Michihiko ; Doi, Wataru ; Hayashi, Kazumasa ; Takenaka, Syunsuke ; Fukaya, Yoshie ; Kimura, Ryosuke</creatorcontrib><description>Acquired cystic disease (ACD)‐associated renal cell carcinoma (RCC) has recently been established. Herein we report the sixth case of ACD‐associated RCC with a sarcomatoid change. The patient was a 77‐year‐old man who regularly underwent hemodialysis for 14 years due to chronic renal failure resulting from IgA nephropathy. On computed tomography, a large right RCC was observed with contrast enhancement in the arterial phase. A nodular protrusion into the perirenal fat was detected. Right nephrectomy was performed under laparoscopy. Surgically resected specimens revealed a tan‐to‐yellow tumor (95 × 75 × 55 mm) with a whitish nodule (20 × 15 × 15 mm) invading into the perirenal fat. Histopathologically, the large carcinoma component of the tumor displayed a cribriform or microcystic growth pattern with deposition of oxalate crystals. The whitish nodule corresponded to the sarcomatoid component, and the spindled and pleomorphic tumor cells showed diffuse positivity of p53 on immunohistochemistry. Fluorescence in situ hybridization revealed trisomy of chromosomes 3 and 16 in the carcinoma component, as was expected from the literature. In addition, increased polysomy of these chromosomes was also observed in the sarcomatoid component. This finding may be related to the development of the sarcomatoid component along with the TP53 mutation.</description><identifier>ISSN: 1320-5463</identifier><identifier>EISSN: 1440-1827</identifier><identifier>DOI: 10.1111/pin.12232</identifier><identifier>PMID: 25424516</identifier><language>eng</language><publisher>Australia</publisher><subject>acquired cystic disease‐associated renal cell carcinoma ; Aged ; Carcinoma, Renal Cell - genetics ; Carcinoma, Renal Cell - pathology ; chromosome 16 ; chromosome 3 ; Chromosome Aberrations ; Chromosomes, Human, Pair 16 - genetics ; Chromosomes, Human, Pair 3 - genetics ; E‐cadherin ; Humans ; In Situ Hybridization, Fluorescence ; Kidney Diseases, Cystic - complications ; Kidney Neoplasms - genetics ; Kidney Neoplasms - pathology ; Male ; N‐cadherin ; polysomy ; sarcomatoid ; Trisomy ; Tumor Suppressor Protein p53 - genetics</subject><ispartof>Pathology international, 2015-02, Vol.65 (2), p.89-94</ispartof><rights>2014 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd</rights><rights>2014 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3492-685120e23885a85c181c710705ec086b517d72778d8d816b8f1f7f3745691d2e3</citedby><cites>FETCH-LOGICAL-c3492-685120e23885a85c181c710705ec086b517d72778d8d816b8f1f7f3745691d2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpin.12232$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpin.12232$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25424516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tajima, Shogo</creatorcontrib><creatorcontrib>Waki, Michihiko</creatorcontrib><creatorcontrib>Doi, Wataru</creatorcontrib><creatorcontrib>Hayashi, Kazumasa</creatorcontrib><creatorcontrib>Takenaka, Syunsuke</creatorcontrib><creatorcontrib>Fukaya, Yoshie</creatorcontrib><creatorcontrib>Kimura, Ryosuke</creatorcontrib><title>Acquired cystic disease‐associated renal cell carcinoma with a focal sarcomatoid component: Report of a case showing more pronounced polysomy of chromosomes 3 and 16 in the sarcomatoid component</title><title>Pathology international</title><addtitle>Pathol Int</addtitle><description>Acquired cystic disease (ACD)‐associated renal cell carcinoma (RCC) has recently been established. Herein we report the sixth case of ACD‐associated RCC with a sarcomatoid change. The patient was a 77‐year‐old man who regularly underwent hemodialysis for 14 years due to chronic renal failure resulting from IgA nephropathy. On computed tomography, a large right RCC was observed with contrast enhancement in the arterial phase. A nodular protrusion into the perirenal fat was detected. Right nephrectomy was performed under laparoscopy. Surgically resected specimens revealed a tan‐to‐yellow tumor (95 × 75 × 55 mm) with a whitish nodule (20 × 15 × 15 mm) invading into the perirenal fat. Histopathologically, the large carcinoma component of the tumor displayed a cribriform or microcystic growth pattern with deposition of oxalate crystals. The whitish nodule corresponded to the sarcomatoid component, and the spindled and pleomorphic tumor cells showed diffuse positivity of p53 on immunohistochemistry. Fluorescence in situ hybridization revealed trisomy of chromosomes 3 and 16 in the carcinoma component, as was expected from the literature. In addition, increased polysomy of these chromosomes was also observed in the sarcomatoid component. This finding may be related to the development of the sarcomatoid component along with the TP53 mutation.</description><subject>acquired cystic disease‐associated renal cell carcinoma</subject><subject>Aged</subject><subject>Carcinoma, Renal Cell - genetics</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>chromosome 16</subject><subject>chromosome 3</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human, Pair 16 - genetics</subject><subject>Chromosomes, Human, Pair 3 - genetics</subject><subject>E‐cadherin</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Kidney Diseases, Cystic - complications</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - pathology</subject><subject>Male</subject><subject>N‐cadherin</subject><subject>polysomy</subject><subject>sarcomatoid</subject><subject>Trisomy</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><issn>1320-5463</issn><issn>1440-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctu1TAQhiMEoqWw4AWQl7BI67HjS9lVFZRKFSAE68jHmXCMEju1Ex1lxyPwUDxJn4Q5nMIKPJIvM5_-GfmvqufAT4HW2RTiKQghxYPqGJqG12CFeUh3KXitGi2PqielfOMcjNT8cXUkVCMaBfq4-nnhb5eQsWN-LXPwrAsFXcG77z9cKckHN1MtY3QD8zjQ5rIPMY2O7cK8ZY71yVOtUJqScwqklMYpRYzza_YJp5RnlnoCPcmysk27EL-yMWVkU04xLdFThykNa0njukf9Nqcx0QsLk8zFjoFmIbJ5i__u87R61Luh4LP786T68vbN58t39c2Hq-vLi5vay-Zc1NoqEByFtFY5qzxY8Aa44Qo9t3qjwHRGGGM7CtAb20Nvemkapc-hEyhPqpcHXRr8dsEyt2Mo-19xEdNSWtBKNNJYwQl9dUB9TqVk7Nsph9HltQXe7k1rybT2t2nEvriXXTYjdn_JPy4RcHYAdmHA9f9K7cfr9wfJX4nwpKE</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Tajima, Shogo</creator><creator>Waki, Michihiko</creator><creator>Doi, Wataru</creator><creator>Hayashi, Kazumasa</creator><creator>Takenaka, Syunsuke</creator><creator>Fukaya, Yoshie</creator><creator>Kimura, Ryosuke</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>Acquired cystic disease‐associated renal cell carcinoma with a focal sarcomatoid component: Report of a case showing more pronounced polysomy of chromosomes 3 and 16 in the sarcomatoid component</title><author>Tajima, Shogo ; Waki, Michihiko ; Doi, Wataru ; Hayashi, Kazumasa ; Takenaka, Syunsuke ; Fukaya, Yoshie ; Kimura, Ryosuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3492-685120e23885a85c181c710705ec086b517d72778d8d816b8f1f7f3745691d2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>acquired cystic disease‐associated renal cell carcinoma</topic><topic>Aged</topic><topic>Carcinoma, Renal Cell - genetics</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>chromosome 16</topic><topic>chromosome 3</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human, Pair 16 - genetics</topic><topic>Chromosomes, Human, Pair 3 - genetics</topic><topic>E‐cadherin</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Kidney Diseases, Cystic - complications</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - pathology</topic><topic>Male</topic><topic>N‐cadherin</topic><topic>polysomy</topic><topic>sarcomatoid</topic><topic>Trisomy</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tajima, Shogo</creatorcontrib><creatorcontrib>Waki, Michihiko</creatorcontrib><creatorcontrib>Doi, Wataru</creatorcontrib><creatorcontrib>Hayashi, Kazumasa</creatorcontrib><creatorcontrib>Takenaka, Syunsuke</creatorcontrib><creatorcontrib>Fukaya, Yoshie</creatorcontrib><creatorcontrib>Kimura, Ryosuke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tajima, Shogo</au><au>Waki, Michihiko</au><au>Doi, Wataru</au><au>Hayashi, Kazumasa</au><au>Takenaka, Syunsuke</au><au>Fukaya, Yoshie</au><au>Kimura, Ryosuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acquired cystic disease‐associated renal cell carcinoma with a focal sarcomatoid component: Report of a case showing more pronounced polysomy of chromosomes 3 and 16 in the sarcomatoid component</atitle><jtitle>Pathology international</jtitle><addtitle>Pathol Int</addtitle><date>2015-02</date><risdate>2015</risdate><volume>65</volume><issue>2</issue><spage>89</spage><epage>94</epage><pages>89-94</pages><issn>1320-5463</issn><eissn>1440-1827</eissn><abstract>Acquired cystic disease (ACD)‐associated renal cell carcinoma (RCC) has recently been established. Herein we report the sixth case of ACD‐associated RCC with a sarcomatoid change. The patient was a 77‐year‐old man who regularly underwent hemodialysis for 14 years due to chronic renal failure resulting from IgA nephropathy. On computed tomography, a large right RCC was observed with contrast enhancement in the arterial phase. A nodular protrusion into the perirenal fat was detected. Right nephrectomy was performed under laparoscopy. Surgically resected specimens revealed a tan‐to‐yellow tumor (95 × 75 × 55 mm) with a whitish nodule (20 × 15 × 15 mm) invading into the perirenal fat. Histopathologically, the large carcinoma component of the tumor displayed a cribriform or microcystic growth pattern with deposition of oxalate crystals. The whitish nodule corresponded to the sarcomatoid component, and the spindled and pleomorphic tumor cells showed diffuse positivity of p53 on immunohistochemistry. Fluorescence in situ hybridization revealed trisomy of chromosomes 3 and 16 in the carcinoma component, as was expected from the literature. In addition, increased polysomy of these chromosomes was also observed in the sarcomatoid component. This finding may be related to the development of the sarcomatoid component along with the TP53 mutation.</abstract><cop>Australia</cop><pmid>25424516</pmid><doi>10.1111/pin.12232</doi><tpages>6</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1320-5463 |
ispartof | Pathology international, 2015-02, Vol.65 (2), p.89-94 |
issn | 1320-5463 1440-1827 |
language | eng |
recordid | cdi_proquest_miscellaneous_1652437820 |
source | MEDLINE; Access via Wiley Online Library |
subjects | acquired cystic disease‐associated renal cell carcinoma Aged Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology chromosome 16 chromosome 3 Chromosome Aberrations Chromosomes, Human, Pair 16 - genetics Chromosomes, Human, Pair 3 - genetics E‐cadherin Humans In Situ Hybridization, Fluorescence Kidney Diseases, Cystic - complications Kidney Neoplasms - genetics Kidney Neoplasms - pathology Male N‐cadherin polysomy sarcomatoid Trisomy Tumor Suppressor Protein p53 - genetics |
title | Acquired cystic disease‐associated renal cell carcinoma with a focal sarcomatoid component: Report of a case showing more pronounced polysomy of chromosomes 3 and 16 in the sarcomatoid component |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-05T17%3A31%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acquired%20cystic%20disease%E2%80%90associated%20renal%20cell%20carcinoma%20with%20a%20focal%20sarcomatoid%20component:%20Report%20of%20a%20case%20showing%20more%20pronounced%20polysomy%20of%20chromosomes%203%20and%2016%20in%20the%20sarcomatoid%20component&rft.jtitle=Pathology%20international&rft.au=Tajima,%20Shogo&rft.date=2015-02&rft.volume=65&rft.issue=2&rft.spage=89&rft.epage=94&rft.pages=89-94&rft.issn=1320-5463&rft.eissn=1440-1827&rft_id=info:doi/10.1111/pin.12232&rft_dat=%3Cproquest_cross%3E1652437820%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1652437820&rft_id=info:pmid/25424516&rfr_iscdi=true |