HPLC analysis of blood–brain barrier penetration of 4-fluorodeprenyl

•A reversed-phase HPLC method was developed and validated for the determination of 4-fluorodeprenyl.•The level of 4-fluorodeprenyl was monitored in various body compartments of rats.•Definite blood–brain barrier penetration of 4-fluorodeprenyl was stated. Validated HPLC analysis was developed in ord...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2015-01, Vol.102, p.529-534
Hauptverfasser:	Pöstényi, Zita, Tekes, Kornélia, Tóth-Molnár, Edit, Kalász, Huba
Format:	Artikel
Sprache:	eng
Schlagworte:	(−)-4-Fluorodeprenyl Animals Biological Transport - physiology Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Blood–Brain barrier (BBB) Brain - drug effects Brain - metabolism Chemistry Techniques, Analytical - methods Chromatography, High Pressure Liquid - methods HPLC Lacrimal gland Male Rats Rats, Wistar Selegiline - analogs & derivatives Selegiline - analysis Selegiline - metabolism Selegiline - pharmacology
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