Intraperitoneal and subcutaneous injections of the TLR9 agonist ODN 1668 in rats: Brain inflammatory responses are related to peripheral IL-6 rather than interferons
Abstract Subcutaneous or intraperitoneal administration of Toll-like receptor (TLR)-9 agonist, ODN 1668 caused moderate fever and anorexia. In comparison to stimulation of other intracellular TLRs, activation of TLR9 did not result in pronounced peripheral induction of interferons, but rather induce...
Gespeichert in:
| Veröffentlicht in: | Journal of neuroimmunology 2014-12, Vol.277 (1), p.105-117 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 117 |
|---|---|
| container_issue | 1 |
| container_start_page | 105 |
| container_title | Journal of neuroimmunology |
| container_volume | 277 |
| creator | Damm, J Wiegand, F Harden, L.M Wenisch, S Gerstberger, R Rummel, C Roth, J |
| description | Abstract Subcutaneous or intraperitoneal administration of Toll-like receptor (TLR)-9 agonist, ODN 1668 caused moderate fever and anorexia. In comparison to stimulation of other intracellular TLRs, activation of TLR9 did not result in pronounced peripheral induction of interferons, but rather induced interleukin-6. Expression of cytokines (TNFα, IL-1β) and inducible forms of enzymes for prostaglandin E2 synthesis occurred in the brain, in conjunction with a moderate activation of the transcription factors STAT3 and NF-IL6 in brain endothelial cells. The lack of a septic-like state in ODN 1668-treated rats reinforces the therapeutic value of this drug. |
| doi_str_mv | 10.1016/j.jneuroim.2014.10.007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1652437159</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0165572814009382</els_id><sourcerecordid>1652437159</sourcerecordid><originalsourceid>FETCH-LOGICAL-c493t-33ea91324336d1556a8a1e176742d5665541b857f05f9620887e374dbadb06113</originalsourceid><addsrcrecordid>eNqFUktv1DAQjhCIbgt_ofKRS7Z-2-GAgPJaaUUlKGfLSSbUIbEX20HaH8T_xNG2HLhwsmf0PTTzTVVdErwlmMircTt6WGJw85Ziwktzi7F6VG2IVrTWnJLH1aYARS0U1WfVeUojxkQw3jytzqjgUlCtNtXvnc_RHiC6HDzYCVnfo7S03ZKth7Ak5PwIXXbBJxQGlO8A3e6_NMh-D96ljG7efUZESl1wKNqcXqK30Za_88Nk59nmEI8oQjoUAUjIRijVZDP0KAe0Gh_uIBbj3b6Wq0KpiotdFTLEAWIhPqueDHZK8Pz-vai-fXh_e_2p3t983F2_2dcdb1iuGQPbEEY5Y7InQkirLQGipOK0F1IKwUmrhRqwGBpJsdYKmOJ9a_sWS0LYRfXipHuI4ecCKZvZpQ6m6bQLU_ZZxBURTYHKE7SLIaUIgzlEN9t4NASbNSIzmoeIzBrR2i8RFeLlvcfSztD_pT1kUgCvTwAok_5yEE3qHPgOehdLEqYP7v8er_6R6CbnXWenH3CENIYl-rJHQ0yiBpuv66Gsd0I4xg3TlP0Bq7i7nw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652437159</pqid></control><display><type>article</type><title>Intraperitoneal and subcutaneous injections of the TLR9 agonist ODN 1668 in rats: Brain inflammatory responses are related to peripheral IL-6 rather than interferons</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Damm, J ; Wiegand, F ; Harden, L.M ; Wenisch, S ; Gerstberger, R ; Rummel, C ; Roth, J</creator><creatorcontrib>Damm, J ; Wiegand, F ; Harden, L.M ; Wenisch, S ; Gerstberger, R ; Rummel, C ; Roth, J</creatorcontrib><description>Abstract Subcutaneous or intraperitoneal administration of Toll-like receptor (TLR)-9 agonist, ODN 1668 caused moderate fever and anorexia. In comparison to stimulation of other intracellular TLRs, activation of TLR9 did not result in pronounced peripheral induction of interferons, but rather induced interleukin-6. Expression of cytokines (TNFα, IL-1β) and inducible forms of enzymes for prostaglandin E2 synthesis occurred in the brain, in conjunction with a moderate activation of the transcription factors STAT3 and NF-IL6 in brain endothelial cells. The lack of a septic-like state in ODN 1668-treated rats reinforces the therapeutic value of this drug.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2014.10.007</identifier><identifier>PMID: 25465287</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Allergy and Immunology ; Animals ; Cytokines ; Dinoprostone - metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drinking - drug effects ; Drug Administration Routes ; Eating - drug effects ; Encephalitis - chemically induced ; Encephalitis - metabolism ; Fever ; Gene Expression Regulation - drug effects ; Immune-to-brain signaling ; Inflammatory transcription factors ; Injections, Intraperitoneal ; Injections, Subcutaneous ; Interferons ; Interferons - genetics ; Interferons - metabolism ; Interleukin-6 - genetics ; Interleukin-6 - metabolism ; Male ; Motor Activity - drug effects ; Neurology ; Oligodeoxyribonucleotides - toxicity ; Rats ; Rats, Wistar ; Time Factors ; Toll-Like Receptor 9 - agonists ; Toll-Like Receptor 9 - chemistry ; Toll-like receptors</subject><ispartof>Journal of neuroimmunology, 2014-12, Vol.277 (1), p.105-117</ispartof><rights>Elsevier B.V.</rights><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-33ea91324336d1556a8a1e176742d5665541b857f05f9620887e374dbadb06113</citedby><cites>FETCH-LOGICAL-c493t-33ea91324336d1556a8a1e176742d5665541b857f05f9620887e374dbadb06113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2014.10.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25465287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Damm, J</creatorcontrib><creatorcontrib>Wiegand, F</creatorcontrib><creatorcontrib>Harden, L.M</creatorcontrib><creatorcontrib>Wenisch, S</creatorcontrib><creatorcontrib>Gerstberger, R</creatorcontrib><creatorcontrib>Rummel, C</creatorcontrib><creatorcontrib>Roth, J</creatorcontrib><title>Intraperitoneal and subcutaneous injections of the TLR9 agonist ODN 1668 in rats: Brain inflammatory responses are related to peripheral IL-6 rather than interferons</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract Subcutaneous or intraperitoneal administration of Toll-like receptor (TLR)-9 agonist, ODN 1668 caused moderate fever and anorexia. In comparison to stimulation of other intracellular TLRs, activation of TLR9 did not result in pronounced peripheral induction of interferons, but rather induced interleukin-6. Expression of cytokines (TNFα, IL-1β) and inducible forms of enzymes for prostaglandin E2 synthesis occurred in the brain, in conjunction with a moderate activation of the transcription factors STAT3 and NF-IL6 in brain endothelial cells. The lack of a septic-like state in ODN 1668-treated rats reinforces the therapeutic value of this drug.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Cytokines</subject><subject>Dinoprostone - metabolism</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drinking - drug effects</subject><subject>Drug Administration Routes</subject><subject>Eating - drug effects</subject><subject>Encephalitis - chemically induced</subject><subject>Encephalitis - metabolism</subject><subject>Fever</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Immune-to-brain signaling</subject><subject>Inflammatory transcription factors</subject><subject>Injections, Intraperitoneal</subject><subject>Injections, Subcutaneous</subject><subject>Interferons</subject><subject>Interferons - genetics</subject><subject>Interferons - metabolism</subject><subject>Interleukin-6 - genetics</subject><subject>Interleukin-6 - metabolism</subject><subject>Male</subject><subject>Motor Activity - drug effects</subject><subject>Neurology</subject><subject>Oligodeoxyribonucleotides - toxicity</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Time Factors</subject><subject>Toll-Like Receptor 9 - agonists</subject><subject>Toll-Like Receptor 9 - chemistry</subject><subject>Toll-like receptors</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUktv1DAQjhCIbgt_ofKRS7Z-2-GAgPJaaUUlKGfLSSbUIbEX20HaH8T_xNG2HLhwsmf0PTTzTVVdErwlmMircTt6WGJw85Ziwktzi7F6VG2IVrTWnJLH1aYARS0U1WfVeUojxkQw3jytzqjgUlCtNtXvnc_RHiC6HDzYCVnfo7S03ZKth7Ak5PwIXXbBJxQGlO8A3e6_NMh-D96ljG7efUZESl1wKNqcXqK30Za_88Nk59nmEI8oQjoUAUjIRijVZDP0KAe0Gh_uIBbj3b6Wq0KpiotdFTLEAWIhPqueDHZK8Pz-vai-fXh_e_2p3t983F2_2dcdb1iuGQPbEEY5Y7InQkirLQGipOK0F1IKwUmrhRqwGBpJsdYKmOJ9a_sWS0LYRfXipHuI4ecCKZvZpQ6m6bQLU_ZZxBURTYHKE7SLIaUIgzlEN9t4NASbNSIzmoeIzBrR2i8RFeLlvcfSztD_pT1kUgCvTwAok_5yEE3qHPgOehdLEqYP7v8er_6R6CbnXWenH3CENIYl-rJHQ0yiBpuv66Gsd0I4xg3TlP0Bq7i7nw</recordid><startdate>20141215</startdate><enddate>20141215</enddate><creator>Damm, J</creator><creator>Wiegand, F</creator><creator>Harden, L.M</creator><creator>Wenisch, S</creator><creator>Gerstberger, R</creator><creator>Rummel, C</creator><creator>Roth, J</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141215</creationdate><title>Intraperitoneal and subcutaneous injections of the TLR9 agonist ODN 1668 in rats: Brain inflammatory responses are related to peripheral IL-6 rather than interferons</title><author>Damm, J ; Wiegand, F ; Harden, L.M ; Wenisch, S ; Gerstberger, R ; Rummel, C ; Roth, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-33ea91324336d1556a8a1e176742d5665541b857f05f9620887e374dbadb06113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Cytokines</topic><topic>Dinoprostone - metabolism</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drinking - drug effects</topic><topic>Drug Administration Routes</topic><topic>Eating - drug effects</topic><topic>Encephalitis - chemically induced</topic><topic>Encephalitis - metabolism</topic><topic>Fever</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Immune-to-brain signaling</topic><topic>Inflammatory transcription factors</topic><topic>Injections, Intraperitoneal</topic><topic>Injections, Subcutaneous</topic><topic>Interferons</topic><topic>Interferons - genetics</topic><topic>Interferons - metabolism</topic><topic>Interleukin-6 - genetics</topic><topic>Interleukin-6 - metabolism</topic><topic>Male</topic><topic>Motor Activity - drug effects</topic><topic>Neurology</topic><topic>Oligodeoxyribonucleotides - toxicity</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Time Factors</topic><topic>Toll-Like Receptor 9 - agonists</topic><topic>Toll-Like Receptor 9 - chemistry</topic><topic>Toll-like receptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Damm, J</creatorcontrib><creatorcontrib>Wiegand, F</creatorcontrib><creatorcontrib>Harden, L.M</creatorcontrib><creatorcontrib>Wenisch, S</creatorcontrib><creatorcontrib>Gerstberger, R</creatorcontrib><creatorcontrib>Rummel, C</creatorcontrib><creatorcontrib>Roth, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Damm, J</au><au>Wiegand, F</au><au>Harden, L.M</au><au>Wenisch, S</au><au>Gerstberger, R</au><au>Rummel, C</au><au>Roth, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraperitoneal and subcutaneous injections of the TLR9 agonist ODN 1668 in rats: Brain inflammatory responses are related to peripheral IL-6 rather than interferons</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2014-12-15</date><risdate>2014</risdate><volume>277</volume><issue>1</issue><spage>105</spage><epage>117</epage><pages>105-117</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract Subcutaneous or intraperitoneal administration of Toll-like receptor (TLR)-9 agonist, ODN 1668 caused moderate fever and anorexia. In comparison to stimulation of other intracellular TLRs, activation of TLR9 did not result in pronounced peripheral induction of interferons, but rather induced interleukin-6. Expression of cytokines (TNFα, IL-1β) and inducible forms of enzymes for prostaglandin E2 synthesis occurred in the brain, in conjunction with a moderate activation of the transcription factors STAT3 and NF-IL6 in brain endothelial cells. The lack of a septic-like state in ODN 1668-treated rats reinforces the therapeutic value of this drug.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25465287</pmid><doi>10.1016/j.jneuroim.2014.10.007</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 2014-12, Vol.277 (1), p.105-117 |
| issn | 0165-5728 1872-8421 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1652437159 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Allergy and Immunology Animals Cytokines Dinoprostone - metabolism Disease Models, Animal Dose-Response Relationship, Drug Drinking - drug effects Drug Administration Routes Eating - drug effects Encephalitis - chemically induced Encephalitis - metabolism Fever Gene Expression Regulation - drug effects Immune-to-brain signaling Inflammatory transcription factors Injections, Intraperitoneal Injections, Subcutaneous Interferons Interferons - genetics Interferons - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Male Motor Activity - drug effects Neurology Oligodeoxyribonucleotides - toxicity Rats Rats, Wistar Time Factors Toll-Like Receptor 9 - agonists Toll-Like Receptor 9 - chemistry Toll-like receptors |
| title | Intraperitoneal and subcutaneous injections of the TLR9 agonist ODN 1668 in rats: Brain inflammatory responses are related to peripheral IL-6 rather than interferons |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T07%3A18%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Intraperitoneal%20and%20subcutaneous%20injections%20of%20the%20TLR9%20agonist%20ODN%201668%20in%20rats:%20Brain%20inflammatory%20responses%20are%20related%20to%20peripheral%20IL-6%20rather%20than%20interferons&rft.jtitle=Journal%20of%20neuroimmunology&rft.au=Damm,%20J&rft.date=2014-12-15&rft.volume=277&rft.issue=1&rft.spage=105&rft.epage=117&rft.pages=105-117&rft.issn=0165-5728&rft.eissn=1872-8421&rft_id=info:doi/10.1016/j.jneuroim.2014.10.007&rft_dat=%3Cproquest_cross%3E1652437159%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1652437159&rft_id=info:pmid/25465287&rft_els_id=1_s2_0_S0165572814009382&rfr_iscdi=true |